Radiation therapy of metastatic pheochromocytoma: Case report and review of the literature

Lio Yu, Adrienne M. Fleckman, Manjeet Chadha, Evan Sacks, Claresa Levetan, Bhadrasain Vikram

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Malignant pheochromocytomas are rare tumors, which are considered radioresistant on the basis of little information. We report a patient, with cranial nerve deficits from a pheochromocytoma metastatic to the parasellar region, who promptly responded to radiation therapy (2,500 cGy) with reversal of neurologic deficit. The disease recurred 2 years later and again promptly responded upon treatment to 2,000 cGy. Hepatic metastases were controlled for over 1 year with 3,240 cGy. The radiotherapy of pheochromocytoma and chemodectoma is reviewed, and the similarities between the two kinds of tumor are discussed. We speculate that a higher initial radiation dose might have resulted in a more sustained remission in our patient and recommend doses of 4,0005,000 cGy if they can be safely administered, in 4-5 weeks for pheochromocytomas.

Original languageEnglish
Pages (from-to)389-393
Number of pages5
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume19
Issue number4
DOIs
StatePublished - 1996
Externally publishedYes

Keywords

  • Brain Neoplasms
  • Liver neoplasms
  • Neoplasm metastasis
  • Nerve Compression syndromes
  • Paraganglioma
  • Pheochromocytoma
  • Radiotherapy
  • Review
  • Therapy

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