Radiation therapy for adenoid cystic carcinoma of the head and neck

Carlos A. Rodriguez-Russo, Jacqueline C. Junn, Sue S. Yom, Richard L. Bakst

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Adenoid cystic carcinoma of the head and neck is an uncommon malignancy that can arise in the major or minor salivary glands. Perineural invasion (PNI) is an extremely frequent finding in cases of adenoid cystic carcinoma (ACC) that can be associated with significant patient morbidity and poor prognosis. By contrast, ACC rarely demonstrates lymphovascular space invasion thereby making PNI the major avenue for metastasis and a driver of treatment rationale and design. Radiotherapy is often utilized post-operatively to improve locoregional control or as a primary therapy in unresectable disease. Here we aim to review the role of radiotherapy in the management of this malignancy with a focus on target delineation and treatment regimens in the definitive, recurrent, and metastatic settings.

Original languageEnglish
Article number6335
Issue number24
StatePublished - 1 Dec 2021


  • Adenoid cystic carcinoma
  • Perineural invasion
  • Radiotherapy


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