TY - JOUR
T1 - Radiation Segmentectomy for Hepatocellular Carcinoma
AU - Serhal, Muhamad
AU - Dadrass, Farnaz
AU - Kim, Edward
AU - Lewandowski, Robert J.
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024/2
Y1 - 2024/2
N2 - The application of trans-arterial radioembolization (TARE) with Yttrium-90, historically a palliative treatment option for patients with advanced hepatocellular carcinoma (HCC), is evolving. Radiation segmentectomy (RADSEG), the segmental delivery of an ablative radiation dose, is a treatment option for patients with earlier-stage HCC. This review presents an in-depth exploration of RADSEG, emphasizing its technical considerations, dosimetry advancements, and patient selection. The integration of RADSEG into the Barcelona Clinic Liver Cancer (BCLC) paradigm will be highlighted. RADSEG outcomes concerning safety and efficacy will be explored and compared with traditional locoregional cancer treatments like trans-arterial chemoembolization (TACE), percutaneous thermal ablation, and surgical resection, with an eye on future directions and considerations.
AB - The application of trans-arterial radioembolization (TARE) with Yttrium-90, historically a palliative treatment option for patients with advanced hepatocellular carcinoma (HCC), is evolving. Radiation segmentectomy (RADSEG), the segmental delivery of an ablative radiation dose, is a treatment option for patients with earlier-stage HCC. This review presents an in-depth exploration of RADSEG, emphasizing its technical considerations, dosimetry advancements, and patient selection. The integration of RADSEG into the Barcelona Clinic Liver Cancer (BCLC) paradigm will be highlighted. RADSEG outcomes concerning safety and efficacy will be explored and compared with traditional locoregional cancer treatments like trans-arterial chemoembolization (TACE), percutaneous thermal ablation, and surgical resection, with an eye on future directions and considerations.
KW - Barcelona Clinic Liver Cancer paradigm
KW - hepatocellular carcinoma
KW - radiation segmentectomy
KW - radioembolization
UR - http://www.scopus.com/inward/record.url?scp=85185855893&partnerID=8YFLogxK
U2 - 10.3390/curroncol31020045
DO - 10.3390/curroncol31020045
M3 - Review article
C2 - 38392039
AN - SCOPUS:85185855893
SN - 1718-7729
VL - 31
SP - 617
EP - 628
JO - Current Oncology
JF - Current Oncology
IS - 2
ER -