Radiation dose and cancer risk estimates in 16-slice computed tomography coronary angiography

Andrew J. Einstein, Javier Sanz, Santo Dellegrottaglie, Margherita Milite, Marc Sirol, Milena Henzlova, Sanjay Rajagopalan

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Background: Recent advances have led to a rapid increase in the number of computed tomography coronary angiography (CTCA) studies performed. Whereas several studies have reported the effective dose, there are no data available on cancer risk for current CTCA protocols. Methods and Results: Effective and organ doses were estimated, by use of scanner-derived parameters and Monte Carlo methods, for 50 patients having 16-slice CTCA performed for clinical indications. Lifetime attributable risks were estimated with models developed in the National Academies' Biological Effects of Ionizing Radiation VII report. The effective dose of a complete CTCA averaged 9.5 mSv, whereas that of a complete study, including calcium scoring when indicated, averaged 11.7 mSv. Calcium scoring increased effective dose by 25%, whereas tube current modulation reduced it by 34% and was more effective at lower heart rates. Organ doses to the lungs and female breast were highest. The lifetime attributable risk of cancer incidence from CTCA averaged approximately 1 in 1,600 but varied widely among patients, being highest in younger women. For all patients, the greatest risk was from lung cancer. Conclusions: CTCA is associated with non-negligible risk of malignancy. Doses can be reduced by careful attention to scanning protocol.

Original languageEnglish
Pages (from-to)232-240
Number of pages9
JournalJournal of Nuclear Cardiology
Issue number2
StatePublished - Mar 2008


  • Computed tomography coronary angiography
  • effective dose
  • radiation


Dive into the research topics of 'Radiation dose and cancer risk estimates in 16-slice computed tomography coronary angiography'. Together they form a unique fingerprint.

Cite this