TY - JOUR
T1 - Racial/ethnic differences in the epidemiology of ovarian cancer
T2 - A pooled analysis of 12 case-control studies
AU - On behalf of the African American Cancer Epidemiology Study and the Ovarian Cancer Association Consortium
AU - Australian ovarian cancer study group
AU - Peres, Lauren C.
AU - Risch, Harvey
AU - Terry, Kathryn L.
AU - MWebb, Penelope
AU - Goodman, Marc T.
AU - Wu, Anna H.
AU - Alberg, Anthony J.
AU - Bandera, Elisa V.
AU - Barnholtz-Sloan, Jill
AU - Bondy, Melissa L.
AU - Cote, Michele L.
AU - Funkhouser, Ellen
AU - Moorman, Patricia G.
AU - Peters, Edward S.
AU - Schwartz, Ann G.
AU - Terry, Paul D.
AU - Manichaikul, Ani
AU - Abbott, Sarah E.
AU - Camacho, Fabian
AU - Jordan, Susan J.
AU - Nagle, Christina M.
AU - Rossing, Mary Anne
AU - Doherty, Jennifer A.
AU - Modugno, Francesmary
AU - Moysich, Kirsten
AU - Ness, Roberta
AU - Berchuck, Andrew
AU - Cook, Linda
AU - Le, Nhu
AU - Brooks-Wilson, Angela
AU - Sieh, Weiva
AU - Whittemore, Alice
AU - McGuire, Valerie
AU - Rothstein, Joseph
AU - Anton-Culver, Hoda
AU - Ziogas, Argyrios
AU - Pearce, Celeste L.
AU - Tseng, Chiuchen
AU - Pike, Malcom
AU - Schildkraut, Joellen M.
N1 - Funding Information:
This work was supported by the National Institutes of Health (R01 CA142081 to AACES; R01 CA074850 and CA080742 to CON; R01 CA112523 and CA087538 to DOV; R01 CA58598, N01 CN55424 and N01 PC67001 to HAW; K07 CA080668, R01 CA95023 and P50 CA159981 to HOP; R01 CA076016 to NCO; R01 CA054419 and P50 CA105009 to NEC; R01 CA160669 to OVA; U01 CA71966, R01 CA16056 and K07 CA143047 to STA; U01 CA69417 for recruitment of controls by the Cancer Prevention Institute of California; R01 CA058860 to UCI; P01 CA17054, P30 CA14089, R01 CA61132, N01 PC67010, R03 CA113148, R03 CA115195 and N01 CN025403 to USC; and R01 CA207260 to AACES, NCO and USC); the Department of Defense (DAMD17– 02–1–0669 to HOP; DAMD17–02–1–0666 to NCO; W81XWH-10–1–02802 to NEC); the Canadian Institutes of Health (MOP- 86727 to OVA); the Lon V. Smith Foundation (LVS-39420 to UCI); the California Cancer Research Program (00–01389V-20170 and 2II0200 to USC); the U.S. Army Medical Research and Material Command (DAMD17–01–1–0729 to AUS); the National Health & Medical Research Council of Australia (199600 and 400281 to AUS); and the Cancer Councils of New South Wales, Victoria, Queensland, South Australia and Tasmania, Cancer Foundation of Western Australia (Multi-State Application Numbers 191, 211 and 182 to AUS).
Publisher Copyright:
© The Author 2017; Published by Oxford University Press on behalf of the International Epidemiological Association all rights reserved.
PY - 2018/4
Y1 - 2018/4
N2 - Background: Ovarian cancer incidence differs substantially by race/ethnicity, but the reasons for this are not well understood. Data were pooled from the African American Cancer Epidemiology Study (AACES) and 11 case-control studies in the Ovarian Cancer Association Consortium (OCAC) to examine racial/ethnic differences in epidemiological characteristics with suspected involvement in epithelial ovarian cancer (EOC) aetiology. Methods: We used multivariable logistic regression to estimate associations for 17 reproductive, hormonal and lifestyle characteristics and EOC risk by race/ethnicity among 10 924 women with invasive EOC (8918 Non-Hispanic Whites, 433 Hispanics, 911 Blacks, 662 Asian/Pacific Islanders) and 16 150 controls (13 619 Non-Hispanic Whites, 533 Hispanics, 1233 Blacks, 765 Asian/Pacific Islanders). Likelihood ratio tests were used to evaluate heterogeneity in the risk factor associations by race/ethnicity. Results: We observed statistically significant racial/ethnic heterogeneity for hysterectomy and EOC risk (P=0.008), where the largest odds ratio (OR) was observed in Black women [OR=1.64, 95% confidence interval (CI)=1.34-2.02] compared with other racial/ ethnic groups. Although not statistically significant, the associations for parity, firstdegree family history of ovarian or breast cancer, and endometriosis varied by race/ethnicity. Asian/Pacific Islanders had the greatest magnitude of association for parity (≥3 births: OR=0.38, 95% CI=0.28-0.54), and Black women had the largest ORs for family history (OR=1.77, 95% CI=1.42-2.21) and endometriosis (OR=2.42, 95% CI=1.65- 3.55). Conclusions: Although racial/ethnic heterogeneity was observed for hysterectomy, our findings support the validity of EOC risk factors across all racial/ethnic groups, and further suggest that any racial/ethnic population with a higher prevalence of a modifiable risk factor should be targeted to disseminate information about prevention.
AB - Background: Ovarian cancer incidence differs substantially by race/ethnicity, but the reasons for this are not well understood. Data were pooled from the African American Cancer Epidemiology Study (AACES) and 11 case-control studies in the Ovarian Cancer Association Consortium (OCAC) to examine racial/ethnic differences in epidemiological characteristics with suspected involvement in epithelial ovarian cancer (EOC) aetiology. Methods: We used multivariable logistic regression to estimate associations for 17 reproductive, hormonal and lifestyle characteristics and EOC risk by race/ethnicity among 10 924 women with invasive EOC (8918 Non-Hispanic Whites, 433 Hispanics, 911 Blacks, 662 Asian/Pacific Islanders) and 16 150 controls (13 619 Non-Hispanic Whites, 533 Hispanics, 1233 Blacks, 765 Asian/Pacific Islanders). Likelihood ratio tests were used to evaluate heterogeneity in the risk factor associations by race/ethnicity. Results: We observed statistically significant racial/ethnic heterogeneity for hysterectomy and EOC risk (P=0.008), where the largest odds ratio (OR) was observed in Black women [OR=1.64, 95% confidence interval (CI)=1.34-2.02] compared with other racial/ ethnic groups. Although not statistically significant, the associations for parity, firstdegree family history of ovarian or breast cancer, and endometriosis varied by race/ethnicity. Asian/Pacific Islanders had the greatest magnitude of association for parity (≥3 births: OR=0.38, 95% CI=0.28-0.54), and Black women had the largest ORs for family history (OR=1.77, 95% CI=1.42-2.21) and endometriosis (OR=2.42, 95% CI=1.65- 3.55). Conclusions: Although racial/ethnic heterogeneity was observed for hysterectomy, our findings support the validity of EOC risk factors across all racial/ethnic groups, and further suggest that any racial/ethnic population with a higher prevalence of a modifiable risk factor should be targeted to disseminate information about prevention.
UR - http://www.scopus.com/inward/record.url?scp=85050130094&partnerID=8YFLogxK
U2 - 10.1093/IJE/DYX252
DO - 10.1093/IJE/DYX252
M3 - Article
C2 - 29211900
AN - SCOPUS:85050130094
SN - 0300-5771
VL - 47
SP - 460
EP - 472
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
IS - 2
ER -