TY - JOUR
T1 - Racial/Ethnic differences in clinical and biochemical type 2 diabetes mellitus risk factors in children
AU - Rosenbaum, Michael
AU - Fennoy, Ilene
AU - Accacha, Siham
AU - Altshuler, Lisa
AU - Carey, Dennis E.
AU - Holleran, Stephen
AU - Rapaport, Robert
AU - Shelov, Steven P.
AU - Speiser, Phyllis W.
AU - Ten, S.
AU - Bhangoo, Amrit
AU - Boucher-Berry, Claudia
AU - Espinal, Yomery
AU - Gupta, Rishi
AU - Hassoun, Abeer A.
AU - Iazetti, Loretta
AU - Jean-Jacques, Fabienne
AU - Jean, Amy M.
AU - Klein, Michelle L.
AU - Levine, Robet
AU - Lowell, Barbara
AU - Michel, Lesley
AU - Rosenfeld, Warren
PY - 2013/10
Y1 - 2013/10
N2 - Objective To examine whether periadolescent children demonstrate the significant racial/ethnic differences in body fatness relative to BMI and in the prevalence and relationship of body composition to risk factors for type 2 diabetes (T2DM) as in adults. Design and Methods Family history of obesity and T2DM, anthropometry, insulin sensitivity and secretory capacity, lipids, and cytokines (IL-6, CRP, TNF-α, and adiponectin) were examined in a cohort of 994 middle school students (47% male, 53%, female; 12% African American, 14% East Asian, 13% South Asian, 9% Caucasian, 44% Hispanic, and 8% other). Results Fractional body fat content was significantly greater at any BMI among South Asians. There were racial/ethnic specific differences in lipid profiles, insulin secretory capacity, insulin sensitivity, and inflammatory markers corrected for body fatness that are similar to those seen in adults. Family history of T2DM was associated with lower insulin secretory capacity while family history of obesity was more associated with insulin resistance. Conclusions Children show some of the same racial/ethnic differences in risk factors for adiposity-related comorbidities as adults. BMI and waist circumference cutoffs to identify children at-risk for adiposity-related comorbidities should be adjusted by racial/ethnic group as well as other variables such as birthweight and family history.
AB - Objective To examine whether periadolescent children demonstrate the significant racial/ethnic differences in body fatness relative to BMI and in the prevalence and relationship of body composition to risk factors for type 2 diabetes (T2DM) as in adults. Design and Methods Family history of obesity and T2DM, anthropometry, insulin sensitivity and secretory capacity, lipids, and cytokines (IL-6, CRP, TNF-α, and adiponectin) were examined in a cohort of 994 middle school students (47% male, 53%, female; 12% African American, 14% East Asian, 13% South Asian, 9% Caucasian, 44% Hispanic, and 8% other). Results Fractional body fat content was significantly greater at any BMI among South Asians. There were racial/ethnic specific differences in lipid profiles, insulin secretory capacity, insulin sensitivity, and inflammatory markers corrected for body fatness that are similar to those seen in adults. Family history of T2DM was associated with lower insulin secretory capacity while family history of obesity was more associated with insulin resistance. Conclusions Children show some of the same racial/ethnic differences in risk factors for adiposity-related comorbidities as adults. BMI and waist circumference cutoffs to identify children at-risk for adiposity-related comorbidities should be adjusted by racial/ethnic group as well as other variables such as birthweight and family history.
UR - http://www.scopus.com/inward/record.url?scp=84885378243&partnerID=8YFLogxK
U2 - 10.1002/oby.20483
DO - 10.1002/oby.20483
M3 - Article
C2 - 23596082
AN - SCOPUS:84885378243
SN - 1930-7381
VL - 21
SP - 2081
EP - 2090
JO - Obesity
JF - Obesity
IS - 10
ER -