Racial susceptibility for QT prolongation in acute drug overdoses

Alex F. Manini, Barry Stimmel, David Vlahov

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Background and Purpose QT prolongation independently predicts adverse cardiovascular events in suspected poisoning. We aimed to evaluate the association between race and drug-induced QT prolongation for patients with acute overdose. Methods This was a cross-sectional observational study at two urban teaching hospitals. Consecutive adult ED patients with acute drug overdose were prospectively enrolled over a two year period. The primary outcome, long-QT, was defined using standard criteria: QTc > 470 ms in females and > 460 ms in males. The association between race and drug-induced QT prolongation was tested, considering several confounding variables. Results In 472 patients analyzed (46% female, mean age 42.3), QT prolongation occurred in 12.7%. Blacks had two-fold increased odds of drug-induced QT prolongation (OR 2.01, CI 1.03-3.91) and Hispanics had 48% decreased odds of drug-induced QT prolongation (OR 0.52, CI 0.29-0.94). Conclusions We found significant racial susceptibility to drug-induced QT prolongation in this large urban study of acute overdoses.

Original languageEnglish
Pages (from-to)244-250
Number of pages7
JournalJournal of Electrocardiology
Volume47
Issue number2
DOIs
StatePublished - 2014

Keywords

  • Overdose
  • QT prolongation
  • Racial differences

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