Racial and ethnic minority patient participation in N-of-1 trials: Perspectives of healthcare providers and patients

Lyndonna Marrast, Joseph Conigliaro, Camille Chan, Eun Ji Kim, Joan Duer-Hefele, Michael A. Diefenbach, Karina W. Davidson

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Aim: Patients from racial and ethnic minority backgrounds in the USA have historically been under-represented in research trials. Understanding their viewpoints regarding participation in N-of-1 trials is imperative as we design and implement these studies. Materials & methods: We conducted six focus groups of racial and ethnic minority patients (n = 25) and providers (n = 9). We used content analysis to identify themes. Results: Our results noted the importance of considering family members in N-of-1 trial recruitment and participation, patients' desire for education as a design feature, for ‘lifestyle' changes as a treatment option and for use of nonevidence-based treatments in the design of future N-of-1 trials. Conclusion: Personalized trials have the potential to change the way we deliver primary care and improve disparities for minorities.

Original languageEnglish
Pages (from-to)347-359
Number of pages13
JournalPersonalized Medicine
Volume18
Issue number4
DOIs
StatePublished - Jul 2021
Externally publishedYes

Keywords

  • N-of-1 trial
  • focus group
  • personalized trial
  • perspectives
  • racial and ethnic minority populations
  • research participation

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