Racial and ethnic differences in epithelial ovarian cancer risk: an analysis from the Ovarian Cancer Association Consortium

Nicola S. Meagher, Kami K. White, Lynne R. Wilkens, Elisa V. Bandera, Andrew Berchuck, Michael E. Carney, Daniel W. Cramer, Kara L. Cushing-Haugen, Susan Jordan, Scott H. Kaufmann, Nhu D. Le, Malcolm C. Pike, Marjorie Riggan, Bo Qin, Joseph H. Rothstein, Linda Titus, Stacey J. Winham, Hoda Anton-Culver, Jennifer A. Doherty, Ellen L. GoodeCeleste Leigh Pearce, Harvey A. Risch, Penelope M. Webb, Linda S. Cook, Marc T. Goodman, Holly R. Harris, Loic Le Marchand, Valerie McGuire, Paul D.P. Pharoah, Danja Sarink, Joellen M. Schildkraut, Weiva Sieh, Kathryn L. Terry, Pamela J. Thompson, Alice S. Whittemore, Anna H. Wu, Lauren C. Peres, Melissa A. Merritt

Research output: Contribution to journalArticlepeer-review

Abstract

Limited estimates exist on risk factors for epithelial ovarian cancer (EOC) in Asian, Hispanic, and Native Hawaiian/Pacific Islander women. Participants in this study included 1734 Asian (n = 785 case and 949 control participants), 266 Native Hawaiian/Pacific Islander (n = 99 case and 167 control participants), 1149 Hispanic (n = 505 case and 644 control participants), and 24 189 White (n = 9981 case and 14 208 control participants) from 11 studies in the Ovarian Cancer Association Consortium. Logistic regression models estimated odds ratios (ORs) and 95% CIs for risk associations by race and ethnicity. Heterogeneity in EOC risk associations by race and ethnicity (P ≤.02) was observed for oral contraceptive (OC) use, parity, tubal ligation, and smoking. We observed inverse associations with EOC risk for OC use and parity across all groups; associations were strongest in Native Hawaiian/Pacific Islander and Asian women. The inverse association for tubal ligation with risk was most pronounced for Native Hawaiian/Pacific Islander participants (odds ratio (OR) = 0.25; 95% CI, 0.13-0.48) compared with Asian and White participants (OR = 0.68 [95% CI, 0.51-0.90] and OR = 0.78 [95% CI, 0.73-0.85], respectively). Differences in EOC risk factor associations were observed across racial and ethnic groups, which could be due, in part, to varying prevalence of EOC histotypes. Inclusion of greater diversity in future studies is essential to inform prevention strategies.

Original languageEnglish
Pages (from-to)1242-1252
Number of pages11
JournalAmerican Journal of Epidemiology
Volume193
Issue number9
DOIs
StatePublished - Sep 2024

Keywords

  • ethnicity
  • ovarian cancer
  • race
  • risk factors

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