Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents

Jonathan R. Young; Song X. Huang; Irene Chen; Thomas F. Walsh; Robert J. DeVita; Matthew J. Wyvratt; Mark T. Goulet; Ning Ren; Jane Lo; Yi Tien Yang; Joel B. Yudkovitz; Kang Cheng; Roy G. Smith

doi:10.1016/S0960-894X(00)00318-8

Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents

Jonathan R. Young, Song X. Huang, Irene Chen, Thomas F. Walsh, Robert J. DeVita, Matthew J. Wyvratt, Mark T. Goulet, Ning Ren, Jane Lo, Yi Tien Yang, Joel B. Yudkovitz, Kang Cheng, Roy G. Smith

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30 Scopus citations

Abstract

A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to be optimal. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	1723-1727
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	15
DOIs	https://doi.org/10.1016/S0960-894X(00)00318-8
State	Published - 7 Aug 2000
Externally published	Yes

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Young, J. R., Huang, S. X., Chen, I., Walsh, T. F., DeVita, R. J., Wyvratt, M. J., Goulet, M. T., Ren, N., Lo, J., Yang, Y. T., Yudkovitz, J. B., Cheng, K., & Smith, R. G. (2000). Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents. Bioorganic and Medicinal Chemistry Letters, 10(15), 1723-1727. https://doi.org/10.1016/S0960-894X(00)00318-8

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abstract = "A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to be optimal. (C) 2000 Elsevier Science Ltd. All rights reserved.",

author = "Young, {Jonathan R.} and Huang, {Song X.} and Irene Chen and Walsh, {Thomas F.} and DeVita, {Robert J.} and Wyvratt, {Matthew J.} and Goulet, {Mark T.} and Ning Ren and Jane Lo and Yang, {Yi Tien} and Yudkovitz, {Joel B.} and Kang Cheng and Smith, {Roy G.}",

year = "2000",

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doi = "10.1016/S0960-894X(00)00318-8",

language = "English",

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Young, JR, Huang, SX, Chen, I, Walsh, TF, DeVita, RJ, Wyvratt, MJ, Goulet, MT, Ren, N, Lo, J, Yang, YT, Yudkovitz, JB, Cheng, K & Smith, RG 2000, 'Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents', Bioorganic and Medicinal Chemistry Letters, vol. 10, no. 15, pp. 1723-1727. https://doi.org/10.1016/S0960-894X(00)00318-8

TY - JOUR

T1 - Quinolones as gonadotropin releasing hormone (GnRH) antagonists

T2 - Simultaneous optimization of the C(3)-aryl and C(6)-substituents

AU - Young, Jonathan R.

AU - Huang, Song X.

AU - Chen, Irene

AU - Walsh, Thomas F.

AU - DeVita, Robert J.

AU - Wyvratt, Matthew J.

AU - Goulet, Mark T.

AU - Ren, Ning

AU - Lo, Jane

AU - Yang, Yi Tien

AU - Yudkovitz, Joel B.

AU - Cheng, Kang

AU - Smith, Roy G.

PY - 2000/8/7

Y1 - 2000/8/7

N2 - A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to be optimal. (C) 2000 Elsevier Science Ltd. All rights reserved.

AB - A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to be optimal. (C) 2000 Elsevier Science Ltd. All rights reserved.

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DO - 10.1016/S0960-894X(00)00318-8

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AN - SCOPUS:0034618152

SN - 0960-894X

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 15

ER -

Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents

Abstract

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