Aberrant migration of GABAergic interneurons during cortical neurodevelopment is implicated in Timothy Syndrome, yet the underlying mechanisms remain elusive. In this issue of Cell Stem Cell, Birey et al. model developing brain circuitry using "assembloids" from patients, characterizing a bimodal mechanism of mechano-chemically driven interneuron migration inefficiencies.

Original languageEnglish
Pages (from-to)181-183
Number of pages3
JournalCell Stem Cell
Issue number2
StatePublished - 3 Feb 2022


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