Questioning the role of rebound firing in the cerebellum

Karina Alvĩa; Joy T. Walter; Adam Kohn; Graham Ellis-Davies; Kamran Khodakhah

doi:10.1038/nn.2195

Questioning the role of rebound firing in the cerebellum

Karina Alvĩa, Joy T. Walter, Adam Kohn, Graham Ellis-Davies, Kamran Khodakhah

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100 Scopus citations

Abstract

A key component of recent theories on cerebellar function is rebound firing in neurons of the deep cerebellar nuclei (DCN). Despite the robustness of this phenomenon in vitro, in vivo studies have provided little evidence for its prevalence. We found that intact mouse or rat DCN neurons rarely showed rebound firing under physiological conditions in vitro or in vivo. These observations necessitate a critical re-evaluation of recent cerebellar models.

Original language	English
Pages (from-to)	1256-1258
Number of pages	3
Journal	Nature Neuroscience
Volume	11
Issue number	11
DOIs	https://doi.org/10.1038/nn.2195
State	Published - Nov 2008
Externally published	Yes

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title = "Questioning the role of rebound firing in the cerebellum",

abstract = "A key component of recent theories on cerebellar function is rebound firing in neurons of the deep cerebellar nuclei (DCN). Despite the robustness of this phenomenon in vitro, in vivo studies have provided little evidence for its prevalence. We found that intact mouse or rat DCN neurons rarely showed rebound firing under physiological conditions in vitro or in vivo. These observations necessitate a critical re-evaluation of recent cerebellar models.",

author = "Karina Alvĩa and Walter, {Joy T.} and Adam Kohn and Graham Ellis-Davies and Kamran Khodakhah",

note = "Funding Information: We thank members of the Khodakhah laboratory for helpful comments and discussion. This work was supported by grants from the US National Institutes of Health and the Human Frontier Science Program (NS050808, NS054251, GM53395, GM65473 and ND44564).",

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AU - Ellis-Davies, Graham

AU - Khodakhah, Kamran

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AB - A key component of recent theories on cerebellar function is rebound firing in neurons of the deep cerebellar nuclei (DCN). Despite the robustness of this phenomenon in vitro, in vivo studies have provided little evidence for its prevalence. We found that intact mouse or rat DCN neurons rarely showed rebound firing under physiological conditions in vitro or in vivo. These observations necessitate a critical re-evaluation of recent cerebellar models.

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Questioning the role of rebound firing in the cerebellum

Abstract

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