Quantitative models of mammalian cell signaling pathways

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This teaching resource provides lecture notes and slides for a class on mathematical modeling of mammalian signaling pathways. This lecture was part of the course .Cell Signaling Systems: A Course for Graduate Students. and focused on quantitative modeling. The lecture describes how different types of mathematical representations are applied to different signaling systems to provide insight into how a signaling system controls cell behavior. The development of an ordinary differential equation.based model for a bistable switch and the predictions that can be obtained from the model are described. The lecture concludes with a description of how models can be tested experimentally and modified when the details of the models and the resultant predictive behavior are not confirmed by experimentation.

Original languageEnglish
Article number17tr1
JournalScience Signaling
Issue number7
StatePublished - 19 Feb 2008


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