Quantitative genetic interactions reveal biological modularity

Pedro Beltrao; Gerard Cagney; Nevan J. Krogan

doi:10.1016/j.cell.2010.05.019

Quantitative genetic interactions reveal biological modularity

Pedro Beltrao, Gerard Cagney, Nevan J. Krogan

Research output: Contribution to journal › Short survey › peer-review

135 Scopus citations

Abstract

Traditionally, research has been reductionist, characterizing the individual components of biological systems. But new technologies have increased the size and scope of biological data, and systems approaches have broadened the view of how these components are interconnected. Here, we discuss how quantitative mapping of genetic interactions enhances our view of biological systems, allowing their deeper interrogation across different biological scales.

Original language	English
Pages (from-to)	739-745
Number of pages	7
Journal	Cell
Volume	141
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2010.05.019
State	Published - May 2010
Externally published	Yes

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10.1016/j.cell.2010.05.019

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title = "Quantitative genetic interactions reveal biological modularity",

abstract = "Traditionally, research has been reductionist, characterizing the individual components of biological systems. But new technologies have increased the size and scope of biological data, and systems approaches have broadened the view of how these components are interconnected. Here, we discuss how quantitative mapping of genetic interactions enhances our view of biological systems, allowing their deeper interrogation across different biological scales.",

author = "Pedro Beltrao and Gerard Cagney and Krogan, {Nevan J.}",

note = "Funding Information: We thank Michael Shales and Clement Chu for graphics work and the Krogan lab for helpful discussions. This work was funded by NIH and the Sandler Family. N.J.K. is a Searle Scholar and a W.M. Keck Foundation Young Scholar. P.B. is supported by the Human Frontier Science Program. ",

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AU - Beltrao, Pedro

AU - Cagney, Gerard

AU - Krogan, Nevan J.

N1 - Funding Information: We thank Michael Shales and Clement Chu for graphics work and the Krogan lab for helpful discussions. This work was funded by NIH and the Sandler Family. N.J.K. is a Searle Scholar and a W.M. Keck Foundation Young Scholar. P.B. is supported by the Human Frontier Science Program.

PY - 2010/5

Y1 - 2010/5

N2 - Traditionally, research has been reductionist, characterizing the individual components of biological systems. But new technologies have increased the size and scope of biological data, and systems approaches have broadened the view of how these components are interconnected. Here, we discuss how quantitative mapping of genetic interactions enhances our view of biological systems, allowing their deeper interrogation across different biological scales.

AB - Traditionally, research has been reductionist, characterizing the individual components of biological systems. But new technologies have increased the size and scope of biological data, and systems approaches have broadened the view of how these components are interconnected. Here, we discuss how quantitative mapping of genetic interactions enhances our view of biological systems, allowing their deeper interrogation across different biological scales.

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DO - 10.1016/j.cell.2010.05.019

M3 - Short survey

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SP - 739

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Quantitative genetic interactions reveal biological modularity

Abstract

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