TY - JOUR
T1 - Quantitative fundus autofluorescence in non-neovascular age-related macular degeneration
AU - Orellana-Rios, Jorge
AU - Yokoyama, Sho
AU - Agee, Julia M.
AU - Challa, Nayanika
AU - Bailey Freund, K.
AU - Yannuzzi, Lawrence A.
AU - Theodore Smith, R.
N1 - Publisher Copyright:
© Slack Incorporated. All rights reserved.
PY - 2018/10
Y1 - 2018/10
N2 - BACKGROUND AND OBJECTIVE: To use quantitative fundus autofluorescence (qAF) to analyze different stages of non-neovascular age-related macular degeneration (AMD). PATIENTS AND METHODS: In this cohort study, 38 pseudophakic patients and 36 age-matched controls participated. We performed near-infrared, spectral-domain optical coherence tomography and qAF imaging on 31 pseudophakic eyes and controls of participants older than 60 years with non-neovascular AMD phenotypes using the Spectralis HRA + OCT (Heidelberg Engineering, Heidelberg, Germany). RESULTS: The patients included in this study had a mean age of 83.9 years, and 35.7% patients were men. Mean qAF was higher in control participants than in all patients with AMD (P <.001). According to non-neovascular AMD phenotype, mean qAF levels were significantly lower in eyes with subretinal drusenoid deposits than in control eyes (P <.05). The lowest mean qAF was in patients with geographic atrophy. CONCLUSION: Quantitative fundus autofluorescence of non-neovascular AMD decreases from normal to early to late AMD, suggesting that loss of lipofuscin fluorophores, not increase, signifies AMD progression.
AB - BACKGROUND AND OBJECTIVE: To use quantitative fundus autofluorescence (qAF) to analyze different stages of non-neovascular age-related macular degeneration (AMD). PATIENTS AND METHODS: In this cohort study, 38 pseudophakic patients and 36 age-matched controls participated. We performed near-infrared, spectral-domain optical coherence tomography and qAF imaging on 31 pseudophakic eyes and controls of participants older than 60 years with non-neovascular AMD phenotypes using the Spectralis HRA + OCT (Heidelberg Engineering, Heidelberg, Germany). RESULTS: The patients included in this study had a mean age of 83.9 years, and 35.7% patients were men. Mean qAF was higher in control participants than in all patients with AMD (P <.001). According to non-neovascular AMD phenotype, mean qAF levels were significantly lower in eyes with subretinal drusenoid deposits than in control eyes (P <.05). The lowest mean qAF was in patients with geographic atrophy. CONCLUSION: Quantitative fundus autofluorescence of non-neovascular AMD decreases from normal to early to late AMD, suggesting that loss of lipofuscin fluorophores, not increase, signifies AMD progression.
UR - http://www.scopus.com/inward/record.url?scp=85055079198&partnerID=8YFLogxK
U2 - 10.3928/23258160-20180814-06
DO - 10.3928/23258160-20180814-06
M3 - Article
C2 - 30339266
AN - SCOPUS:85055079198
SN - 2325-8160
VL - 49
SP - S34-S42
JO - Ophthalmic Surgery Lasers and Imaging Retina
JF - Ophthalmic Surgery Lasers and Imaging Retina
IS - 10
ER -