Quantitative autoradiographic analysis of muscarinic cholinergic and GABAA (benzodiazepine) receptors in the forebrain of rats flown on the Soviet Biosatellite COSMOS 2044

Thomas M. Hyde; Li Chun Wu; Igor B. Krasnov; Stephen K. Sigworth; Nancy G. Daunton; Fernando D'Amelio

doi:10.1016/0006-8993(92)91321-5

Quantitative autoradiographic analysis of muscarinic cholinergic and GABA_A (benzodiazepine) receptors in the forebrain of rats flown on the Soviet Biosatellite COSMOS 2044

Thomas M. Hyde, Li Chun Wu, Igor B. Krasnov, Stephen K. Sigworth, Nancy G. Daunton, Fernando D'Amelio

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The quantitative autoradiographic analysis of muscarinic cholinergic and GABA_A (benzodiazepine) receptors was performed on selected regions of the cerebral cortex and striatum of rats flown in the Soviet Biosatellite COSMOS 2044. An age- and strain-matched synchronous ground-based control group was employed for comparison. Muscarinic cholinergic receptor density was found to be significantly lower in the striatum of the flight animals as compared with that in the synchronous control group. No significant differences between flight and synchronous control groups were found in the other regions examined. GABA_A (benzodiazepine) receptors showed no significant differences between the flight and control groups in any of the regions sampled. Although additional studies are needed to reach definitive conclusions, the decrease in muscarinic cholinergic receptors observed in the striatum suggests spaceflight-related alterations in motor activity.

Original language	English
Pages (from-to)	291-294
Number of pages	4
Journal	Brain Research
Volume	593
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(92)91321-5
State	Published - 16 Oct 1992
Externally published	Yes

Keywords

Autoradiography
Cholinergic
Forebrain
Receptor
γ-Aminobutyric acid

Access to Document

10.1016/0006-8993(92)91321-5

Cite this

@article{55f6225df17c4f58b9c184c1a533dd1a,

title = "Quantitative autoradiographic analysis of muscarinic cholinergic and GABAA (benzodiazepine) receptors in the forebrain of rats flown on the Soviet Biosatellite COSMOS 2044",

abstract = "The quantitative autoradiographic analysis of muscarinic cholinergic and GABAA (benzodiazepine) receptors was performed on selected regions of the cerebral cortex and striatum of rats flown in the Soviet Biosatellite COSMOS 2044. An age- and strain-matched synchronous ground-based control group was employed for comparison. Muscarinic cholinergic receptor density was found to be significantly lower in the striatum of the flight animals as compared with that in the synchronous control group. No significant differences between flight and synchronous control groups were found in the other regions examined. GABAA (benzodiazepine) receptors showed no significant differences between the flight and control groups in any of the regions sampled. Although additional studies are needed to reach definitive conclusions, the decrease in muscarinic cholinergic receptors observed in the striatum suggests spaceflight-related alterations in motor activity.",

keywords = "Autoradiography, Cholinergic, Forebrain, Receptor, γ-Aminobutyric acid",

author = "Hyde, \{Thomas M.\} and Wu, \{Li Chun\} and Krasnov, \{Igor B.\} and Sigworth, \{Stephen K.\} and Daunton, \{Nancy G.\} and Fernando D'Amelio",

note = "Funding Information: The authors want to express their appreciation to the Soviet and US scientists for providing the samples used in this study. Funding for this re,arch was provided by NASA-Ames Research Center COSMOS Biospecimen Program. in part by the Intramural Research Program to the Clinical Brain Disorders Branch of the National Institute of Mental tlealth and by NASA Grant NCC 2-449 to the San Jose Sale University Foundation. Special thanks to Dr. Richard E. Grindeland. James P. Connolly and Marilyn F. Vasques for their constant support.",

year = "1992",

month = oct,

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doi = "10.1016/0006-8993(92)91321-5",

language = "English",

volume = "593",

pages = "291--294",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier B.V.",

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T1 - Quantitative autoradiographic analysis of muscarinic cholinergic and GABAA (benzodiazepine) receptors in the forebrain of rats flown on the Soviet Biosatellite COSMOS 2044

AU - Hyde, Thomas M.

AU - Wu, Li Chun

AU - Krasnov, Igor B.

AU - Sigworth, Stephen K.

AU - Daunton, Nancy G.

AU - D'Amelio, Fernando

N1 - Funding Information: The authors want to express their appreciation to the Soviet and US scientists for providing the samples used in this study. Funding for this re,arch was provided by NASA-Ames Research Center COSMOS Biospecimen Program. in part by the Intramural Research Program to the Clinical Brain Disorders Branch of the National Institute of Mental tlealth and by NASA Grant NCC 2-449 to the San Jose Sale University Foundation. Special thanks to Dr. Richard E. Grindeland. James P. Connolly and Marilyn F. Vasques for their constant support.

PY - 1992/10/16

Y1 - 1992/10/16

N2 - The quantitative autoradiographic analysis of muscarinic cholinergic and GABAA (benzodiazepine) receptors was performed on selected regions of the cerebral cortex and striatum of rats flown in the Soviet Biosatellite COSMOS 2044. An age- and strain-matched synchronous ground-based control group was employed for comparison. Muscarinic cholinergic receptor density was found to be significantly lower in the striatum of the flight animals as compared with that in the synchronous control group. No significant differences between flight and synchronous control groups were found in the other regions examined. GABAA (benzodiazepine) receptors showed no significant differences between the flight and control groups in any of the regions sampled. Although additional studies are needed to reach definitive conclusions, the decrease in muscarinic cholinergic receptors observed in the striatum suggests spaceflight-related alterations in motor activity.

AB - The quantitative autoradiographic analysis of muscarinic cholinergic and GABAA (benzodiazepine) receptors was performed on selected regions of the cerebral cortex and striatum of rats flown in the Soviet Biosatellite COSMOS 2044. An age- and strain-matched synchronous ground-based control group was employed for comparison. Muscarinic cholinergic receptor density was found to be significantly lower in the striatum of the flight animals as compared with that in the synchronous control group. No significant differences between flight and synchronous control groups were found in the other regions examined. GABAA (benzodiazepine) receptors showed no significant differences between the flight and control groups in any of the regions sampled. Although additional studies are needed to reach definitive conclusions, the decrease in muscarinic cholinergic receptors observed in the striatum suggests spaceflight-related alterations in motor activity.

KW - Autoradiography

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KW - Forebrain

KW - Receptor

KW - γ-Aminobutyric acid

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