Quantitative assessment of cerebral ventricular volumes in chronic fatigue syndrome

Gudrun Lange, Andrei I. Holodny, John DeLuca, Huey Jen Lee, Xiao Hong Michelle Yan, Jason Steffener, Benjamin H. Natelson

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Previous qualitative volumetric assessment of lateral ventricular enlargement in chronic fatigue syndrome (CFS) has provided evidence for subtle structural changes in the brains of some individuals with CFS. The aim of this pilot study was to determine whether a more sensitive quantitative assessment of the lateral ventricular system would support the previous qualitative findings. In this study, we compared the total lateral ventricular volume, as well as the right and left hemisphere subcomponents in 28 participants with CFS and 15 controls. Ventricular volumes in the CFS group were larger than in control groups, a difference that approached statistical significance. Group differences in ventricular asymmetry were not observed. The results of this study provide further evidence of subtle pathophysiological changes in the brains of participants with CFS.

Original languageEnglish
Pages (from-to)23-30
Number of pages8
JournalApplied Neuropsychology
Issue number1
StatePublished - 2001
Externally publishedYes


  • Brain pathology
  • Chronic fatigue syndrome
  • Lateral ventricle
  • Morphometry
  • Volumetric assessment


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