Quantification of the effect of treatment duration on local-regional failure after definitive concurrent chemotherapy and intensity-modulated radiation therapy for squamous cell carcinoma of the head and neck

Mary E. Platek; Susan A. McCloskey; Myra Cruz; Mark S. Burke; Mary E. Reid; Gregory E. Wilding; Nestor R. Rigual; Saurin R. Popat; Thom R. Loree; Vishal Gupta; Graham W. Warren; Maureen Sullivan; Wesley L. Hicks; Anurag K. Singh

doi:10.1002/hed.23024

Quantification of the effect of treatment duration on local-regional failure after definitive concurrent chemotherapy and intensity-modulated radiation therapy for squamous cell carcinoma of the head and neck

Mary E. Platek, Susan A. McCloskey, Myra Cruz, Mark S. Burke, Mary E. Reid, Gregory E. Wilding, Nestor R. Rigual, Saurin R. Popat, Thom R. Loree, Vishal Gupta, Graham W. Warren, Maureen Sullivan, Wesley L. Hicks, Anurag K. Singh

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Background The purpose of this study was to quantify the effect of treatment duration on locoregional progression after definitive concurrent chemoradiation (CCRT) for squamous cell carcinoma of the head and neck (SCCHN). Methods We conducted a retrospective chart review of patients treated between 2004 and 2010. After a prior analysis, measures were taken to limit therapy beyond 7 weeks. Comparison of outcomes were made between cohorts 1 (2004-2007, n = 78) and 2 (2007-2010, n = 62). Results Median therapy duration was statistically significantly different between cohorts as follows: 51 days, cohort 1 and 46 days, cohort 2 (p <.01). Locoregional progression in cohorts 1 and 2 was 19% and 5% (p =.01), respectively. On multivariate analysis, patients with prolonged treatment (≥57 days) had an 8-fold increase in risk of locoregional progression compared to patients who completed on time (p <.01). Conclusion Treatment duration was a significant predictor of locoregional progression in patients with SCCHN who received definitive CCRT. © 2012 Wiley Periodicals, Inc. Head Neck, 2013

Original language	English
Pages (from-to)	684-688
Number of pages	5
Journal	Head and Neck
Volume	35
Issue number	5
DOIs	https://doi.org/10.1002/hed.23024
State	Published - May 2013
Externally published	Yes

Keywords

anemia
concurrent chemoradiation therapy
squamous cell carcinoma of the head and neck
treatment delay
treatment failure

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10.1002/hed.23024

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Platek, M. E., McCloskey, S. A., Cruz, M., Burke, M. S., Reid, M. E., Wilding, G. E., Rigual, N. R., Popat, S. R., Loree, T. R., Gupta, V., Warren, G. W., Sullivan, M., Hicks, W. L., & Singh, A. K. (2013). Quantification of the effect of treatment duration on local-regional failure after definitive concurrent chemotherapy and intensity-modulated radiation therapy for squamous cell carcinoma of the head and neck. Head and Neck, 35(5), 684-688. https://doi.org/10.1002/hed.23024

@article{deee49eab31b4b9c8b8a4fe932678fa8,

title = "Quantification of the effect of treatment duration on local-regional failure after definitive concurrent chemotherapy and intensity-modulated radiation therapy for squamous cell carcinoma of the head and neck",

abstract = "Background The purpose of this study was to quantify the effect of treatment duration on locoregional progression after definitive concurrent chemoradiation (CCRT) for squamous cell carcinoma of the head and neck (SCCHN). Methods We conducted a retrospective chart review of patients treated between 2004 and 2010. After a prior analysis, measures were taken to limit therapy beyond 7 weeks. Comparison of outcomes were made between cohorts 1 (2004-2007, n = 78) and 2 (2007-2010, n = 62). Results Median therapy duration was statistically significantly different between cohorts as follows: 51 days, cohort 1 and 46 days, cohort 2 (p <.01). Locoregional progression in cohorts 1 and 2 was 19% and 5% (p =.01), respectively. On multivariate analysis, patients with prolonged treatment (≥57 days) had an 8-fold increase in risk of locoregional progression compared to patients who completed on time (p <.01). Conclusion Treatment duration was a significant predictor of locoregional progression in patients with SCCHN who received definitive CCRT. {\textcopyright} 2012 Wiley Periodicals, Inc. Head Neck, 2013",

keywords = "anemia, concurrent chemoradiation therapy, squamous cell carcinoma of the head and neck, treatment delay, treatment failure",

author = "Platek, {Mary E.} and McCloskey, {Susan A.} and Myra Cruz and Burke, {Mark S.} and Reid, {Mary E.} and Wilding, {Gregory E.} and Rigual, {Nestor R.} and Popat, {Saurin R.} and Loree, {Thom R.} and Vishal Gupta and Warren, {Graham W.} and Maureen Sullivan and Hicks, {Wesley L.} and Singh, {Anurag K.}",

year = "2013",

month = may,

doi = "10.1002/hed.23024",

language = "English",

volume = "35",

pages = "684--688",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley & Sons Inc.",

number = "5",

}

Platek, ME, McCloskey, SA, Cruz, M, Burke, MS, Reid, ME, Wilding, GE, Rigual, NR, Popat, SR, Loree, TR, Gupta, V, Warren, GW, Sullivan, M, Hicks, WL & Singh, AK 2013, 'Quantification of the effect of treatment duration on local-regional failure after definitive concurrent chemotherapy and intensity-modulated radiation therapy for squamous cell carcinoma of the head and neck', Head and Neck, vol. 35, no. 5, pp. 684-688. https://doi.org/10.1002/hed.23024

Quantification of the effect of treatment duration on local-regional failure after definitive concurrent chemotherapy and intensity-modulated radiation therapy for squamous cell carcinoma of the head and neck. / Platek, Mary E.; McCloskey, Susan A.; Cruz, Myra et al.
In: Head and Neck, Vol. 35, No. 5, 05.2013, p. 684-688.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Quantification of the effect of treatment duration on local-regional failure after definitive concurrent chemotherapy and intensity-modulated radiation therapy for squamous cell carcinoma of the head and neck

AU - Platek, Mary E.

AU - McCloskey, Susan A.

AU - Cruz, Myra

AU - Burke, Mark S.

AU - Reid, Mary E.

AU - Wilding, Gregory E.

AU - Rigual, Nestor R.

AU - Popat, Saurin R.

AU - Loree, Thom R.

AU - Gupta, Vishal

AU - Warren, Graham W.

AU - Sullivan, Maureen

AU - Hicks, Wesley L.

AU - Singh, Anurag K.

PY - 2013/5

Y1 - 2013/5

N2 - Background The purpose of this study was to quantify the effect of treatment duration on locoregional progression after definitive concurrent chemoradiation (CCRT) for squamous cell carcinoma of the head and neck (SCCHN). Methods We conducted a retrospective chart review of patients treated between 2004 and 2010. After a prior analysis, measures were taken to limit therapy beyond 7 weeks. Comparison of outcomes were made between cohorts 1 (2004-2007, n = 78) and 2 (2007-2010, n = 62). Results Median therapy duration was statistically significantly different between cohorts as follows: 51 days, cohort 1 and 46 days, cohort 2 (p <.01). Locoregional progression in cohorts 1 and 2 was 19% and 5% (p =.01), respectively. On multivariate analysis, patients with prolonged treatment (≥57 days) had an 8-fold increase in risk of locoregional progression compared to patients who completed on time (p <.01). Conclusion Treatment duration was a significant predictor of locoregional progression in patients with SCCHN who received definitive CCRT. © 2012 Wiley Periodicals, Inc. Head Neck, 2013

AB - Background The purpose of this study was to quantify the effect of treatment duration on locoregional progression after definitive concurrent chemoradiation (CCRT) for squamous cell carcinoma of the head and neck (SCCHN). Methods We conducted a retrospective chart review of patients treated between 2004 and 2010. After a prior analysis, measures were taken to limit therapy beyond 7 weeks. Comparison of outcomes were made between cohorts 1 (2004-2007, n = 78) and 2 (2007-2010, n = 62). Results Median therapy duration was statistically significantly different between cohorts as follows: 51 days, cohort 1 and 46 days, cohort 2 (p <.01). Locoregional progression in cohorts 1 and 2 was 19% and 5% (p =.01), respectively. On multivariate analysis, patients with prolonged treatment (≥57 days) had an 8-fold increase in risk of locoregional progression compared to patients who completed on time (p <.01). Conclusion Treatment duration was a significant predictor of locoregional progression in patients with SCCHN who received definitive CCRT. © 2012 Wiley Periodicals, Inc. Head Neck, 2013

KW - anemia

KW - concurrent chemoradiation therapy

KW - squamous cell carcinoma of the head and neck

KW - treatment delay

KW - treatment failure

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U2 - 10.1002/hed.23024

DO - 10.1002/hed.23024

M3 - Article

C2 - 22619040

AN - SCOPUS:84876025731

SN - 1043-3074

VL - 35

SP - 684

EP - 688

JO - Head and Neck

JF - Head and Neck

IS - 5

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