TY - JOUR
T1 - Quality of life and disability in patients with treatment-failure gout
AU - Becker, Michael A.
AU - Schumacher, H. Ralph
AU - Benjamin, Katy L.
AU - Gorevic, Peter
AU - Greenwald, Maria
AU - Fessel, Jeffrey
AU - Edwards, Lawrence
AU - Kawata, Ariane K.
AU - Frank, Lori
AU - Waltrip, Royce
AU - Maroli, Allan
AU - Huang, Bill
AU - Sundy, John S.
AU - Weisman, Michael
AU - Reginato, Antonio
AU - Griffin, Robert
AU - Goldberger, Edward
AU - Simkin, Peter
AU - Morgan, John
AU - Kivitz, Alan
AU - Weitz, Michael
AU - Fung, H. S.Eugene
AU - Fudman, Edward
AU - Cronin, Mary
AU - Peller, Jeffrey S.
AU - Lies, Richard
AU - Block, Joel
AU - Rosenthal, Pamela
AU - Merrill, Joan
AU - Dewees, Guy
PY - 2009/5
Y1 - 2009/5
N2 - Objective. The relationship between self-reported quality of life and disability and disease severity was evaluated in subjects with treatment-failure gout (n = 110) in a prospective, 52-week, observational study. Methods. Subjects had symptomatic crystal-proven gout of at least 2 years' duration and intolerance or refractoriness to conventional urate-lowering therapy. Serum uric acid (sUA) concentration, swollen and tender joint counts, frequency and severity of gout flares, tophus assessments, comorbidities, and patient-reported outcomes data [Medical Outcomes Study Short Form-36 (SF-36), Health Assessment Questionnaire-Damage Index] were collected. Analyses included correlations of patient-reported outcomes with clinical variables and changes in clinical status. Results. Mean age of study subjects was 59 years. Mean scores on SF-36 physical functioning subscales were 34.2-46.8, analogous to persons aged ≥ 75 years in the general population. Subjects with more severe gout at baseline had worse health-related quality of life (HRQOL) in all areas (p < 0.02 for all measures), compared to patients with mild-moderate disease. Number of flares reported in past year, number of tender joints, swollen joints, and tophi correlated significantly with some or all HRQOL and disability measures. sUA was not significantly correlated with any HRQOL or disability measure. Subjects with comorbidities experienced worse physical, but not mental, functioning. Conclusion. Severe gout is associated with poor HRQOL and disability, especially for patients who experience more gout flares and have a greater number of involved joints. Subject perceptions of gout-related functioning and pain severity appear to be highly sensitive indicators of HRQOL and disability. The Journal of Rheumatology
AB - Objective. The relationship between self-reported quality of life and disability and disease severity was evaluated in subjects with treatment-failure gout (n = 110) in a prospective, 52-week, observational study. Methods. Subjects had symptomatic crystal-proven gout of at least 2 years' duration and intolerance or refractoriness to conventional urate-lowering therapy. Serum uric acid (sUA) concentration, swollen and tender joint counts, frequency and severity of gout flares, tophus assessments, comorbidities, and patient-reported outcomes data [Medical Outcomes Study Short Form-36 (SF-36), Health Assessment Questionnaire-Damage Index] were collected. Analyses included correlations of patient-reported outcomes with clinical variables and changes in clinical status. Results. Mean age of study subjects was 59 years. Mean scores on SF-36 physical functioning subscales were 34.2-46.8, analogous to persons aged ≥ 75 years in the general population. Subjects with more severe gout at baseline had worse health-related quality of life (HRQOL) in all areas (p < 0.02 for all measures), compared to patients with mild-moderate disease. Number of flares reported in past year, number of tender joints, swollen joints, and tophi correlated significantly with some or all HRQOL and disability measures. sUA was not significantly correlated with any HRQOL or disability measure. Subjects with comorbidities experienced worse physical, but not mental, functioning. Conclusion. Severe gout is associated with poor HRQOL and disability, especially for patients who experience more gout flares and have a greater number of involved joints. Subject perceptions of gout-related functioning and pain severity appear to be highly sensitive indicators of HRQOL and disability. The Journal of Rheumatology
KW - Disability
KW - Gout
KW - Health-related quality of life
KW - Patient-reported outcomes
KW - Quality of life
UR - https://www.scopus.com/pages/publications/67449099218
U2 - 10.3899/jrheum.071229
DO - 10.3899/jrheum.071229
M3 - Article
C2 - 19332629
AN - SCOPUS:67449099218
SN - 0315-162X
VL - 36
SP - 1041
EP - 1048
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 5
ER -