Quality of Life and Cognitive Function Evaluations and Interventions for Patients with Brain Metastases in the Radiation Oncology Clinic

Jennifer K. Matsui; Haley K. Perlow; Cyril Baiyee; Alex R. Ritter; Mark V. Mishra; Joseph A. Bovi; Vinai Gondi; Paul D. Brown; Ashlee R. Loughan; Heather E. Leeper; Erica Dawson; Joshua D. Palmer

doi:10.3390/cancers14174301

Quality of Life and Cognitive Function Evaluations and Interventions for Patients with Brain Metastases in the Radiation Oncology Clinic

Jennifer K. Matsui, Haley K. Perlow, Cyril Baiyee, Alex R. Ritter, Mark V. Mishra, Joseph A. Bovi, Vinai Gondi, Paul D. Brown, Ashlee R. Loughan, Heather E. Leeper, Erica Dawson, Joshua D. Palmer

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Brain metastases (BMs) account for a disproportionately high percentage of cancer morbidity and mortality. Historically, studies have focused on improving survival outcomes, and recent radiation oncology clinical trials have incorporated HRQOL and cognitive assessments. We are now equipped with a battery of assessments in the radiation oncology clinic, but there is a lack of consensus regarding how to incorporate them in modern clinical practice. Herein, we present validated assessments for BM patients, current recommendations for future clinical studies, and treatment advances that have improved HRQOL and cognitive outcomes for BM patients.

Original language	English
Article number	4301
Journal	Cancers
Volume	14
Issue number	17
DOIs	https://doi.org/10.3390/cancers14174301
State	Published - Sep 2022
Externally published	Yes

Keywords

brain metastases
cognition
cognitive function
quality of life
radiotherapy

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10.3390/cancers14174301

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Matsui, J. K., Perlow, H. K., Baiyee, C., Ritter, A. R., Mishra, M. V., Bovi, J. A., Gondi, V., Brown, P. D., Loughan, A. R., Leeper, H. E., Dawson, E., & Palmer, J. D. (2022). Quality of Life and Cognitive Function Evaluations and Interventions for Patients with Brain Metastases in the Radiation Oncology Clinic. Cancers, 14(17), Article 4301. https://doi.org/10.3390/cancers14174301

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title = "Quality of Life and Cognitive Function Evaluations and Interventions for Patients with Brain Metastases in the Radiation Oncology Clinic",

abstract = "Brain metastases (BMs) account for a disproportionately high percentage of cancer morbidity and mortality. Historically, studies have focused on improving survival outcomes, and recent radiation oncology clinical trials have incorporated HRQOL and cognitive assessments. We are now equipped with a battery of assessments in the radiation oncology clinic, but there is a lack of consensus regarding how to incorporate them in modern clinical practice. Herein, we present validated assessments for BM patients, current recommendations for future clinical studies, and treatment advances that have improved HRQOL and cognitive outcomes for BM patients.",

keywords = "brain metastases, cognition, cognitive function, quality of life, radiotherapy",

author = "Matsui, {Jennifer K.} and Perlow, {Haley K.} and Cyril Baiyee and Ritter, {Alex R.} and Mishra, {Mark V.} and Bovi, {Joseph A.} and Vinai Gondi and Brown, {Paul D.} and Loughan, {Ashlee R.} and Leeper, {Heather E.} and Erica Dawson and Palmer, {Joshua D.}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = sep,

doi = "10.3390/cancers14174301",

language = "English",

volume = "14",

journal = "Cancers",

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publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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T1 - Quality of Life and Cognitive Function Evaluations and Interventions for Patients with Brain Metastases in the Radiation Oncology Clinic

AU - Matsui, Jennifer K.

AU - Perlow, Haley K.

AU - Baiyee, Cyril

AU - Ritter, Alex R.

AU - Mishra, Mark V.

AU - Bovi, Joseph A.

AU - Gondi, Vinai

AU - Brown, Paul D.

AU - Loughan, Ashlee R.

AU - Leeper, Heather E.

AU - Dawson, Erica

AU - Palmer, Joshua D.

PY - 2022/9

Y1 - 2022/9

N2 - Brain metastases (BMs) account for a disproportionately high percentage of cancer morbidity and mortality. Historically, studies have focused on improving survival outcomes, and recent radiation oncology clinical trials have incorporated HRQOL and cognitive assessments. We are now equipped with a battery of assessments in the radiation oncology clinic, but there is a lack of consensus regarding how to incorporate them in modern clinical practice. Herein, we present validated assessments for BM patients, current recommendations for future clinical studies, and treatment advances that have improved HRQOL and cognitive outcomes for BM patients.

AB - Brain metastases (BMs) account for a disproportionately high percentage of cancer morbidity and mortality. Historically, studies have focused on improving survival outcomes, and recent radiation oncology clinical trials have incorporated HRQOL and cognitive assessments. We are now equipped with a battery of assessments in the radiation oncology clinic, but there is a lack of consensus regarding how to incorporate them in modern clinical practice. Herein, we present validated assessments for BM patients, current recommendations for future clinical studies, and treatment advances that have improved HRQOL and cognitive outcomes for BM patients.

KW - brain metastases

KW - cognition

KW - cognitive function

KW - quality of life

KW - radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=85137785667&partnerID=8YFLogxK

U2 - 10.3390/cancers14174301

DO - 10.3390/cancers14174301

M3 - Review article

AN - SCOPUS:85137785667

SN - 2072-6694

VL - 14

JO - Cancers

JF - Cancers

IS - 17

M1 - 4301

ER -

Quality of Life and Cognitive Function Evaluations and Interventions for Patients with Brain Metastases in the Radiation Oncology Clinic

Abstract

Keywords

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