Pyrogen and prostaglandin fever in the rabbit-I: Effects of salicylate and the role of cyclic AMP

C. J. Woolf, G. H. Willies, Helen Laburn, C. Rosendorff

Research output: Contribution to journalArticlepeer-review

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Abstract

Intrahypothalamic injections of dibutyryl cyclic AMP into the rabbit produce a dose-dependent rise in rectal temperature with a short latency of onset. The fevers produced by intravenous administration of a bacterial pyrogen and intrahypothalamic injections of prostaglandin E1 were both significantly potentiated by the simultaneous administration of theophylline, a nucleotide phosphodiesterase inhibitor. This suggests the possibility that both pyrogen and prostaglandin E1 produce fevers via cyclic AMP. Sodium salicylate infused intravenously produced a marked attenuation of the pyrogen fever but was without effect on the prostaglandin E1 fever. Since salicylate inhibits prostaglandin biosynthesis, this result is consistent with the idea that pyrogen fever is mediated via a prostaglandlin.

Original languageEnglish
Pages (from-to)397-403
Number of pages7
JournalNeuropharmacology
Volume14
Issue number5-6
DOIs
StatePublished - 1975
Externally publishedYes

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