Pyoderma gangrenosum

Neal M. Blitz, Donald Rudikoff

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations


Pyoderma gangrenosum (PG) is an idiopathic, painful and destructive condition that usually presents as an ulceration on the pretibial region of the legs. It primarily affects patients with inflammatory bowel disease, arthritis, myeloproliferative disorders and chronic hepatitis, and occasionally affects patients with other conditions, but it may also occur without any associated illness. Since there are no specific serologic or histologic markers for PG, it must be diagnosed clinically. Treatment usually involves immunosuppressant therapy as well as treatment of the underlying disease. The course of PG is unpredictable, and prognosis depends on the extent of the skin lesions at the time of diagnosis, underscoring the need for early and aggressive management.

Original languageEnglish
Pages (from-to)287-297
Number of pages11
JournalMount Sinai Journal of Medicine
Issue number4-5
StatePublished - Sep 2001


  • Chemokines
  • Corticosteroids
  • Cyclosporine
  • Inflammatory bowel disease
  • Neutrophilic dermatoses
  • Pyoderma gangrenosum
  • Tacrolimus


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