Putting a finger on the switch

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The transition from fetal to adult (β-like globin expression is a key step in the maturation of the red blood cell lineage. Two new studies show that the KLF1 zinc finger protein uses direct and indirect means to regulate the final switch from fetal to adult globin expression and that monoallelic loss of KLF1 expression leads to persistence of fetal hemoglobin.

Original languageEnglish
Pages (from-to)733-734
Number of pages2
JournalNature Genetics
Issue number9
StatePublished - Sep 2010
Externally publishedYes


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