Pursuing totipotency: authentic totipotent stem cells in culture

Vikas Malik, Jianlong Wang

Research output: Contribution to journalShort surveypeer-review

10 Scopus citations


Totipotent stem cells are transiently occurring in vivo cells that can form all cell types of the embryo including placenta, with their in vitro counterparts being actively pursued. Subsequently, totipotent-like cells are established with variable robustness and biological relevance. Here, we summarize current progress on capturing these cells in culture.

Original languageEnglish
Pages (from-to)632-636
Number of pages5
JournalTrends in Genetics
Issue number7
StatePublished - Jul 2022
Externally publishedYes


  • 2 cell-like cells
  • blastoids
  • expanded/extended pluripotent stem cells
  • totipotent blastomere-like cells
  • totipotent stem cells
  • totipotent-like stem cells


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