Purinergic receptors: Elucidating the role of these immune mediators in HIV-1 fusion

Tracey L. Freeman, Talia H. Swartz

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Purinergic receptors are inflammatory mediators activated by extracellular nucleotides released by dying or injured cells. Several studies have described an important role for these receptors in HIV-1 entry, particularly regarding their activity on HIV-1 viral membrane fusion. Several reports identify purinergic receptor antagonists that inhibit HIV-1 membrane fusion; these drugs are suspected to act through antagonizing Env-chemokine receptor interactions. They also appear to abrogate activity of downstream mediators that potentiate activation of the NLRP3 inflammasome pathway. Here we review the literature on purinergic receptors, the drugs that inhibit their function, and the evidence implicating these receptors in HIV-1 entry.

Original languageEnglish
Article number290
JournalViruses
Volume12
Issue number3
DOIs
StatePublished - 2020

Keywords

  • Fusion
  • HIV-1
  • Inflammation
  • Purinergic

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