Pump delivery of azidothymidine: Potential for constant concentrations and improved brain delivery

J. M. Gallo, L. N. Clark, J. T. Rubino

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Azidothymidine (AZT) was administered to rats by an osmotic pump and by a multiple-dose regimen. The cannula attached to the pump was placed in the external carotid artery to facilitate intraarterial delivery of AZT. Mean AZT serum and brain concentrations measured over seven days in the pump group were relatively constant and indicated an increase in brain uptake com- pared to animals that received the multiple-dose regimen.

Original languageEnglish
Pages (from-to)249-253
Number of pages5
JournalJournal of Controlled Release
Volume9
Issue number3
DOIs
StatePublished - Aug 1989
Externally publishedYes

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