Abstract
Background The present study was designed to investigate the effect of topical antiglaucoma drugs on Peak Pulse Blood Volume (PPBV; German abbreviation: PGBV) in cynomolgus monkey eyes without (CMNG; German abbreviation: RA-KTL) and with lasersurgically induced glaucoma (CMG; German abbreviation: RA-LHDG). Methods CMG unilaterally received 2-3 laser treatments so as to develop the lasered-eye glaucoma model. Intraocular pressure (IOP; German abbreviation: IOD) and Ocular Pulse Amplitude were measured and PPBV was determined until the glaucoma model had stabilized. Consecutively topical antiglaucoma drugs (epinephrine, paraaminoclonidine, pilocarpine, timolol) were investigated in 4-8 animals in CMNG and CMG eyes. Results IOP and PPBV were not significantly altered in CMNG. In the CMG eyes epinephrine and paraaminoclonidine did not significantly alter IOP or PPBV, whereas pilocarpine and timolol sig. (p<0.01) reduced lOP and significantly (p < 0.05) increased PPBV. Conclusion With respect to improved PPBV in the CMG eye the rank order of drug effectiveness is timolol > pilocarpine > paraaminoclonidine > epinephrine.
| Translated title of the contribution | Peak pulse blood volume and topical antiglaucomatous drugs in a cynomolgus monkey high tension glaucoma model |
|---|---|
| Original language | German |
| Pages (from-to) | 341-346 |
| Number of pages | 6 |
| Journal | Klinische Monatsblatter fur Augenheilkunde |
| Volume | 213 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1998 |
Keywords
- Experimental primary open angle glaucomas
- Intraocular vascular system
- Ocular pulse amplitude
- Peak pulse blood volume
- Topical glaucoma drugs