Pulsgipfelblutvolumen bei gezielter beeinflussung lokaler perfusionsparameter

Translated title of the contribution: Peak pulse blood volume during manipulation of local perfusion parameters

Karl Georg Schmidt, Andrea V. Rückmann, Volker Klingmüller, Lutz E. Pillunat, Thomas W. Mittag

Research output: Contribution to journalArticlepeer-review

Abstract

Background Choroidal autoregulation is discussed controversially. The present study was designed to investigate for the effect of standardized manipulation of local perfusion parameters on choroidal hemodynamics in cynomolgus monkey eyes with lasersurgically induced glaucoma (CMG; German abbreviation: RA-LHDG). Methods CMG unilaterally received 2-3 laser treatments so as to develop the lasered-eye glaucoma model. Intraocular pressure (IOP; German abbreviation: IOD) and Ocular Pulse Amplitude (OPA) were measured and Peak Pulse Blood Volume (PPBV; German abbreviation: PGBV) was determined. Results In CMG PPBV was not significantly (sig., p > 0.05) altered in laser-treated eyes- despite a sig. (p < 0.05) increase in IOP. Untreated contralateral control eyes of monkeys with an IOP-increase > 5 mm Hg in laser-treated eyes showed a sig. (p < 0.05) increase in PPBV. Conclusion Unchanged PPBV in laser-treated eyes of CMG and an increase in PPBV in control eyes point at a bilateral autoregulatory compensatory mechanism, which is more manifest in eyes with IOPs in the normal range.

Translated title of the contributionPeak pulse blood volume during manipulation of local perfusion parameters
Original languageGerman
Pages (from-to)347-350
Number of pages4
JournalKlinische Monatsblatter fur Augenheilkunde
Volume213
Issue number6
DOIs
StatePublished - Dec 1998

Keywords

  • Autoregulation
  • Choroidocular pulse amplitude
  • Experimental open angle glaucomas
  • Peak pulse blood volume

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