Abstract
Background Choroidal autoregulation is discussed controversially. The present study was designed to investigate for the effect of standardized manipulation of local perfusion parameters on choroidal hemodynamics in cynomolgus monkey eyes with lasersurgically induced glaucoma (CMG; German abbreviation: RA-LHDG). Methods CMG unilaterally received 2-3 laser treatments so as to develop the lasered-eye glaucoma model. Intraocular pressure (IOP; German abbreviation: IOD) and Ocular Pulse Amplitude (OPA) were measured and Peak Pulse Blood Volume (PPBV; German abbreviation: PGBV) was determined. Results In CMG PPBV was not significantly (sig., p > 0.05) altered in laser-treated eyes- despite a sig. (p < 0.05) increase in IOP. Untreated contralateral control eyes of monkeys with an IOP-increase > 5 mm Hg in laser-treated eyes showed a sig. (p < 0.05) increase in PPBV. Conclusion Unchanged PPBV in laser-treated eyes of CMG and an increase in PPBV in control eyes point at a bilateral autoregulatory compensatory mechanism, which is more manifest in eyes with IOPs in the normal range.
Translated title of the contribution | Peak pulse blood volume during manipulation of local perfusion parameters |
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Original language | German |
Pages (from-to) | 347-350 |
Number of pages | 4 |
Journal | Klinische Monatsblatter fur Augenheilkunde |
Volume | 213 |
Issue number | 6 |
DOIs | |
State | Published - Dec 1998 |
Keywords
- Autoregulation
- Choroidocular pulse amplitude
- Experimental open angle glaucomas
- Peak pulse blood volume