Pulmonary hypertension: Novel pathways and emerging therapies inhibitors of cGMP and cAMP metabolism

Yassine Sassi, Jean Sébastien Hulot

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations

Abstract

Cyclic nucleotides (e.g., cAMP and cGMP) are ubiquitous second messengers that affect multiple cell functions including vascular tone and vascular cell proliferation. After production, different processes can regulate the concentration of cyclic nucleotides. Cyclic nucleotides' degradation by phosphodiesterase (PDE) enzymes has well-known roles in regulating cyclic nucleotides concentrations. Recently, recognition of ATP-binding cassette (ABC) transporter contribution to both local and global regulation of cAMP has been acknowledged. Recent data support an important role of cyclic nucleotide efflux in the pathobiology of pulmonary hypertension, thus suggesting that inhibition of cyclic nucleotide efflux proteins might be a useful strategy to prevent and treat PH.

Original languageEnglish
Title of host publicationPharmacotherapy of Pulmonary Hypertension
EditorsMarc Humbert, Johannes-Peter Stasch, Oleg V. Evgenov
Pages513-529
Number of pages17
DOIs
StatePublished - 2013
Externally publishedYes

Publication series

NameHandbook of Experimental Pharmacology
Volume218
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

Keywords

  • Cyclic nucleotides
  • Efflux
  • Multidrug resistance-associated proteins
  • Pulmonary artery

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