Pulmonary artery sarcoma overexpressing platelet-derived growth factor receptor α

Shinnosuke Takemoto; Hiroshi Soda; Keisuke Iwasaki; Takeshi Kitazaki; Makoto Sumiyoshi; Tatsuhiko Harada; Yosuke Dotsu; Daiki Ogawara; Susumu Fukahori; Yuichi Fukuda; Hiroshi Mukae

doi:10.2169/internalmedicine.56.7731

Pulmonary artery sarcoma overexpressing platelet-derived growth factor receptor α

Shinnosuke Takemoto
, Hiroshi Soda
, Keisuke Iwasaki
, Takeshi Kitazaki
, Makoto Sumiyoshi
, Tatsuhiko Harada
, Yosuke Dotsu
, Daiki Ogawara
, Susumu Fukahori
, Yuichi Fukuda
, Hiroshi Mukae

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Pulmonary artery sarcoma is highly malignant and easily metastasizes to the systemic organs. Both the introduction of novel diagnostic procedures and the development of new treatment modalities are required to achieve long-term survival. Several studies have shown that platelet-derived growth factor receptor α (PDGFRα) gene amplification is frequently observed in pulmonary artery sarcoma. PDGFRα is known to be involved in cell proliferation in certain malignancies. PDGFRα may become a potential biological marker in pulmonary artery sarcoma. We report a case in which a diagnosis of pulmonary artery sarcoma overexpressing PDGFRα was made using endovascular catheter biopsy following positron emission tomography with integrated computed tomography (PET/CT) scans.

Original language	English
Pages (from-to)	823-826
Number of pages	4
Journal	Internal Medicine
Volume	56
Issue number	7
DOIs	https://doi.org/10.2169/internalmedicine.56.7731
State	Published - 2017
Externally published	Yes

Keywords

Endovascular catheter biopsy
PDGFRα
PET/CT scans
Pulmonary artery sarcoma

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10.2169/internalmedicine.56.7731

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title = "Pulmonary artery sarcoma overexpressing platelet-derived growth factor receptor α",

abstract = "Pulmonary artery sarcoma is highly malignant and easily metastasizes to the systemic organs. Both the introduction of novel diagnostic procedures and the development of new treatment modalities are required to achieve long-term survival. Several studies have shown that platelet-derived growth factor receptor α (PDGFRα) gene amplification is frequently observed in pulmonary artery sarcoma. PDGFRα is known to be involved in cell proliferation in certain malignancies. PDGFRα may become a potential biological marker in pulmonary artery sarcoma. We report a case in which a diagnosis of pulmonary artery sarcoma overexpressing PDGFRα was made using endovascular catheter biopsy following positron emission tomography with integrated computed tomography (PET/CT) scans.",

keywords = "Endovascular catheter biopsy, PDGFRα, PET/CT scans, Pulmonary artery sarcoma",

author = "Shinnosuke Takemoto and Hiroshi Soda and Keisuke Iwasaki and Takeshi Kitazaki and Makoto Sumiyoshi and Tatsuhiko Harada and Yosuke Dotsu and Daiki Ogawara and Susumu Fukahori and Yuichi Fukuda and Hiroshi Mukae",

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year = "2017",

doi = "10.2169/internalmedicine.56.7731",

language = "English",

volume = "56",

pages = "823--826",

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TY - JOUR

T1 - Pulmonary artery sarcoma overexpressing platelet-derived growth factor receptor α

AU - Takemoto, Shinnosuke

AU - Soda, Hiroshi

AU - Iwasaki, Keisuke

AU - Kitazaki, Takeshi

AU - Sumiyoshi, Makoto

AU - Harada, Tatsuhiko

AU - Dotsu, Yosuke

AU - Ogawara, Daiki

AU - Fukahori, Susumu

AU - Fukuda, Yuichi

AU - Mukae, Hiroshi

PY - 2017

Y1 - 2017

N2 - Pulmonary artery sarcoma is highly malignant and easily metastasizes to the systemic organs. Both the introduction of novel diagnostic procedures and the development of new treatment modalities are required to achieve long-term survival. Several studies have shown that platelet-derived growth factor receptor α (PDGFRα) gene amplification is frequently observed in pulmonary artery sarcoma. PDGFRα is known to be involved in cell proliferation in certain malignancies. PDGFRα may become a potential biological marker in pulmonary artery sarcoma. We report a case in which a diagnosis of pulmonary artery sarcoma overexpressing PDGFRα was made using endovascular catheter biopsy following positron emission tomography with integrated computed tomography (PET/CT) scans.

AB - Pulmonary artery sarcoma is highly malignant and easily metastasizes to the systemic organs. Both the introduction of novel diagnostic procedures and the development of new treatment modalities are required to achieve long-term survival. Several studies have shown that platelet-derived growth factor receptor α (PDGFRα) gene amplification is frequently observed in pulmonary artery sarcoma. PDGFRα is known to be involved in cell proliferation in certain malignancies. PDGFRα may become a potential biological marker in pulmonary artery sarcoma. We report a case in which a diagnosis of pulmonary artery sarcoma overexpressing PDGFRα was made using endovascular catheter biopsy following positron emission tomography with integrated computed tomography (PET/CT) scans.

KW - Endovascular catheter biopsy

KW - PDGFRα

KW - PET/CT scans

KW - Pulmonary artery sarcoma

UR - https://www.scopus.com/pages/publications/85016970592

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DO - 10.2169/internalmedicine.56.7731

M3 - Article

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AN - SCOPUS:85016970592

SN - 0918-2918

VL - 56

SP - 823

EP - 826

JO - Internal Medicine

JF - Internal Medicine

IS - 7

ER -

Pulmonary artery sarcoma overexpressing platelet-derived growth factor receptor α

Abstract

Keywords

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