TY - JOUR
T1 - Psychosomatic digitalis-toxic arrhythmias in guinea pigs
AU - Natelson, Benjamin H.
AU - Cagin, Norman A.
AU - Donner, Kenneth
AU - Hamilton, Bruce E.
N1 - Funding Information:
This study was made possible by grants from the Foundation of the College of Medicine and Dentistry of New Jersey and the American Heart Association, Bergen County and Union County Chapters. BHN is a recipient of a VA Career Development Award. The authors acknowledge the secretarial aide of L. Fallone .
PY - 1978/6/26
Y1 - 1978/6/26
N2 - Adult male guinea pigs were subjected daily to six 1 min tone/light signals, each 5 min apart. For half of the animals, the signal was followed by rump shock 40% of the time (signal, shock group); for the remaining animals, shock was never delivered (signal, no-shock group). Animals in both groups were subjected to weekly injections of ouabain, a fast-acting digitalis glycoside. For the signal, shock group, significantly more potentially lethal arrhythmias began during the signal than the min preceding it. Also, a significantly higher percentage of arrhythmias began during the signal periods for the signal, shock group when compared to the signal, no-shock group. These findings indicate that psychogenic factors may contribute to the development of digitalis-toxic arrhythmias.
AB - Adult male guinea pigs were subjected daily to six 1 min tone/light signals, each 5 min apart. For half of the animals, the signal was followed by rump shock 40% of the time (signal, shock group); for the remaining animals, shock was never delivered (signal, no-shock group). Animals in both groups were subjected to weekly injections of ouabain, a fast-acting digitalis glycoside. For the signal, shock group, significantly more potentially lethal arrhythmias began during the signal than the min preceding it. Also, a significantly higher percentage of arrhythmias began during the signal periods for the signal, shock group when compared to the signal, no-shock group. These findings indicate that psychogenic factors may contribute to the development of digitalis-toxic arrhythmias.
UR - http://www.scopus.com/inward/record.url?scp=0018148908&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(78)90578-7
DO - 10.1016/0024-3205(78)90578-7
M3 - Article
C2 - 672460
AN - SCOPUS:0018148908
SN - 0024-3205
VL - 22
SP - 2245
EP - 2250
JO - Life Sciences
JF - Life Sciences
IS - 24
ER -