Psychosis and brain volume changes during the first five years of schizophrenia

W. Cahn; M. Rais; F. P. Stigter; N. E.M. van Haren; E. Caspers; H. E. Hulshoff Pol; Z. Xu; H. G. Schnack; R. S. Kahn

doi:10.1016/j.euroneuro.2008.10.006

Psychosis and brain volume changes during the first five years of schizophrenia

W. Cahn
, M. Rais
, F. P. Stigter
, N. E.M. van Haren
, E. Caspers
, H. E. Hulshoff Pol
, Z. Xu
, H. G. Schnack
, R. S. Kahn

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

The underlying mechanisms explaining brain volume changes in schizophrenia are not yet understood, but psychosis might be related to these changes. Forty-eight patients with first-episode schizophrenia underwent Magnetic Resonance Imaging brain scanning at inclusion and after five years. An association was found between longer duration of psychosis, larger gray matter volume decrease and larger ventricular volume increase. These findings strongly suggest that psychosis contributes to brain volume reductions found in schizophrenia.

Original language	English
Pages (from-to)	147-151
Number of pages	5
Journal	European Neuropsychopharmacology
Volume	19
Issue number	2
DOIs	https://doi.org/10.1016/j.euroneuro.2008.10.006
State	Published - Feb 2009
Externally published	Yes

Keywords

Brain volumes
First-episode schizophrenia
Longitudinal
Neuroimaging
Psychosis

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10.1016/j.euroneuro.2008.10.006

Cite this

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title = "Psychosis and brain volume changes during the first five years of schizophrenia",

abstract = "The underlying mechanisms explaining brain volume changes in schizophrenia are not yet understood, but psychosis might be related to these changes. Forty-eight patients with first-episode schizophrenia underwent Magnetic Resonance Imaging brain scanning at inclusion and after five years. An association was found between longer duration of psychosis, larger gray matter volume decrease and larger ventricular volume increase. These findings strongly suggest that psychosis contributes to brain volume reductions found in schizophrenia.",

keywords = "Brain volumes, First-episode schizophrenia, Longitudinal, Neuroimaging, Psychosis",

author = "W. Cahn and M. Rais and Stigter, \{F. P.\} and \{van Haren\}, \{N. E.M.\} and E. Caspers and \{Hulshoff Pol\}, \{H. E.\} and Z. Xu and Schnack, \{H. G.\} and Kahn, \{R. S.\}",

year = "2009",

month = feb,

doi = "10.1016/j.euroneuro.2008.10.006",

language = "English",

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AU - Cahn, W.

AU - Rais, M.

AU - Stigter, F. P.

AU - van Haren, N. E.M.

AU - Caspers, E.

AU - Hulshoff Pol, H. E.

AU - Xu, Z.

AU - Schnack, H. G.

AU - Kahn, R. S.

PY - 2009/2

Y1 - 2009/2

N2 - The underlying mechanisms explaining brain volume changes in schizophrenia are not yet understood, but psychosis might be related to these changes. Forty-eight patients with first-episode schizophrenia underwent Magnetic Resonance Imaging brain scanning at inclusion and after five years. An association was found between longer duration of psychosis, larger gray matter volume decrease and larger ventricular volume increase. These findings strongly suggest that psychosis contributes to brain volume reductions found in schizophrenia.

AB - The underlying mechanisms explaining brain volume changes in schizophrenia are not yet understood, but psychosis might be related to these changes. Forty-eight patients with first-episode schizophrenia underwent Magnetic Resonance Imaging brain scanning at inclusion and after five years. An association was found between longer duration of psychosis, larger gray matter volume decrease and larger ventricular volume increase. These findings strongly suggest that psychosis contributes to brain volume reductions found in schizophrenia.

KW - Brain volumes

KW - First-episode schizophrenia

KW - Longitudinal

KW - Neuroimaging

KW - Psychosis

UR - https://www.scopus.com/pages/publications/57749182668

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DO - 10.1016/j.euroneuro.2008.10.006

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EP - 151

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

IS - 2

ER -

Psychosis and brain volume changes during the first five years of schizophrenia

Abstract

Keywords

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