TY - JOUR
T1 - Psychopathology in the young offspring of parents with bipolar disorder
T2 - A controlled pilot study
AU - Hirshfeld-Becker, Dina R.
AU - Biederman, Joseph
AU - Henin, Aude
AU - Faraone, Stephen V.
AU - Dowd, Stephanie T.
AU - De Petrillo, Lillian A.
AU - Markowitz, Sarah M.
AU - Rosenbaum, Jerrold F.
N1 - Funding Information:
This research was supported by National Institute of Mental Health Grant R01 MH-47077-11.
PY - 2006/12/7
Y1 - 2006/12/7
N2 - Studies have suggested that the offspring of parents with bipolar disorder are at risk for a spectrum of psychopathology, but few have focused on children in the youngest age ranges or examined the impact of comorbid parental disorders. We utilized a pre-existing sample of young (mean age: 6.8 years) offspring of parents with bipolar disorder (n = 34), of parents with panic or major depression (n = 179), and of parents with neither mood or anxiety disorder (n = 95). Children were assessed blindly to parental diagnoses using the Schedule for Affective Disorders and Schizophrenia-Epidemiologic version (K-SADS-E). Offspring of bipolar parents had significantly higher rates of disruptive behavior and anxiety disorders than offspring from both of the comparison groups, accounted for by elevated rates of ADHD and overanxious disorder. These comparisons were significant even when lifetime histories of the corresponding categories of comorbid disorders in the parents (disruptive behavior disorders and anxiety disorders) were covaried. In addition, offspring of bipolar parents had increased rates of bipolar I disorder, compared with psychiatric controls. Results support the hypotheses of elevated behavior, anxiety, and mood disorders among offspring at risk for bipolar disorder, and suggest that this psychopathology is already evident in early childhood.
AB - Studies have suggested that the offspring of parents with bipolar disorder are at risk for a spectrum of psychopathology, but few have focused on children in the youngest age ranges or examined the impact of comorbid parental disorders. We utilized a pre-existing sample of young (mean age: 6.8 years) offspring of parents with bipolar disorder (n = 34), of parents with panic or major depression (n = 179), and of parents with neither mood or anxiety disorder (n = 95). Children were assessed blindly to parental diagnoses using the Schedule for Affective Disorders and Schizophrenia-Epidemiologic version (K-SADS-E). Offspring of bipolar parents had significantly higher rates of disruptive behavior and anxiety disorders than offspring from both of the comparison groups, accounted for by elevated rates of ADHD and overanxious disorder. These comparisons were significant even when lifetime histories of the corresponding categories of comorbid disorders in the parents (disruptive behavior disorders and anxiety disorders) were covaried. In addition, offspring of bipolar parents had increased rates of bipolar I disorder, compared with psychiatric controls. Results support the hypotheses of elevated behavior, anxiety, and mood disorders among offspring at risk for bipolar disorder, and suggest that this psychopathology is already evident in early childhood.
KW - Behavior disorders
KW - Children
KW - Mood disorders
UR - http://www.scopus.com/inward/record.url?scp=33751022237&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2005.08.026
DO - 10.1016/j.psychres.2005.08.026
M3 - Article
C2 - 17083985
AN - SCOPUS:33751022237
SN - 0165-1781
VL - 145
SP - 155
EP - 167
JO - Psychiatry Research
JF - Psychiatry Research
IS - 2-3
ER -