TY - JOUR
T1 - Psychoneuroimmunodermatology of atopic dermatitis
T2 - From empiric data to the evolutionary hypothesis
AU - Pallanti, Stefano
AU - Lotti, Torello
AU - Urpe, Mauro
PY - 2005/10
Y1 - 2005/10
N2 - Atopic dermatitis is a pruritic skin disease affecting predominantly young people. There is evidence that psychologic stress constitutes an increased risk for atopy and influences the disease's clinical course. This risk is believed mediated by the effects of stress on neuroimmunoregulation, which in turn modulates the hypersensitivity response and involves immunoglobulin E-mediated inflammation, helper T-cell 2 predominance, and eosinophilia. This article examines theoretic perspectives and other behavioral dimensions, such as maternal caring behavior, infant response to stress, temperament, and the so-called "hygiene hypothesis." The Darwinian framework and the mental scenario are examined. These processes may be akin to the generation of antibodies by the immune system.
AB - Atopic dermatitis is a pruritic skin disease affecting predominantly young people. There is evidence that psychologic stress constitutes an increased risk for atopy and influences the disease's clinical course. This risk is believed mediated by the effects of stress on neuroimmunoregulation, which in turn modulates the hypersensitivity response and involves immunoglobulin E-mediated inflammation, helper T-cell 2 predominance, and eosinophilia. This article examines theoretic perspectives and other behavioral dimensions, such as maternal caring behavior, infant response to stress, temperament, and the so-called "hygiene hypothesis." The Darwinian framework and the mental scenario are examined. These processes may be akin to the generation of antibodies by the immune system.
UR - http://www.scopus.com/inward/record.url?scp=23844514422&partnerID=8YFLogxK
U2 - 10.1016/j.det.2005.05.019
DO - 10.1016/j.det.2005.05.019
M3 - Review article
C2 - 16112446
AN - SCOPUS:23844514422
SN - 0733-8635
VL - 23
SP - 695
EP - 701
JO - Dermatologic Clinics
JF - Dermatologic Clinics
IS - 4 SPEC. ISS.
ER -