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Psychological and behavioural impact of genetic testing smokers for lung cancer risk: A phase II exploratory trial

  • Saskia C. Sanderson
  • , Steve E. Humphries
  • , Christina Hubbart
  • , Eluned Hughes
  • , Martin J. Jarvis
  • , Jane Wardle

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

The behavioural and psychological impact of genetic testing for lung cancer susceptibility was examined among smokers (N = 61) who were randomly allocated to a GSTM1 genetic testing group (with GSTM1-missing or GSTM1-present result) or no-test control group. The GSTM1-missing (higher risk) group reported greater motivation to quit smoking, and both genetic testing groups reported lower depression than the control group at one-week follow-up (p <.05 for all). Differences were not significant at two months follow-up. This study indicates the feasibility of much-needed research into the risks and benefits for individuals of emerging lifestyle-related genetic susceptibility tests.

Original languageEnglish
Pages (from-to)481-494
Number of pages14
JournalJournal of Health Psychology
Volume13
Issue number4
DOIs
StatePublished - May 2008
Externally publishedYes

Keywords

  • Behaviour change
  • Genetic testing
  • Lung cancer
  • Smoking cessation

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