Psychiatric presentation of Hashimoto's encephalopathy

Manuel Arrojo, Maria M. Perez-Rodriguez, Márcia Mota, Ricardo Moreira, Ana Azevedo, Ana Oliveira, Pedro Abreu, Paula Marques, Alzira Silva, Jorge G. Pereira, A. Pacheco Palha, Enrique Baca-Garcia

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


INTRODUCTION: Hashimoto's encephalopathy is an unusual condition that is associated with Hashimoto's thyroiditis. Myoclonus, epileptic seizures, dementia, and disturbances of consciousness are the most common features. CASE REPORT: We present an atypical case of Hashimoto's encephalopathy in a 33-year-old woman who presented with several brief and acute psychotic episodes. After treatment with steroids, there was an improvement in the patient's psychiatric symptoms and electroencephalogram, and antithyroglobulin antibody titers returned to normal levels. CONCLUSIONS: It is our opinion that Hashimoto's encephalopathy should be considered in the differential diagnosis of atypical psychosis, especially because this is a treatable syndrome. This is particularly important in patients with a previous history of thyroid disease, despite current normal thyroid function.

Original languageEnglish
Pages (from-to)200-201
Number of pages2
JournalPsychosomatic Medicine
Issue number2
StatePublished - 2007
Externally publishedYes


  • Encephalopathy
  • Hashimoto's disease
  • Psychiatric symptoms
  • Single-photon emission-computed tomography


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