Psychiatric and social outcome after deep brain stimulation for advanced Parkinson's disease

Judith A. Boel; Vincent J.J. Odekerken; Gert J. Geurtsen; Ben A. Schmand; Danielle C. Cath; Martijn Figee; Pepijn van den Munckhof; Rob J. de Haan; P. Richard Schuurman; Rob M.A. de Bie; Teus van Laar; J. Marc C. van Dijk; Arne Mosch; Carel F.E. Hoffmann; Peter C.G. Nijssen; Guus N. Beute; Jeroen P.P. van Vugt; Mathieu W.P.M. Lenders; M. Fiorella Contarino; Lo J. Bour

doi:10.1002/mds.26468

Psychiatric and social outcome after deep brain stimulation for advanced Parkinson's disease

Judith A. Boel, Vincent J.J. Odekerken, Gert J. Geurtsen, Ben A. Schmand, Danielle C. Cath, Martijn Figee, Pepijn van den Munckhof, Rob J. de Haan, P. Richard Schuurman, Rob M.A. de Bie, Teus van Laar, J. Marc C. van Dijk, Arne Mosch, Carel F.E. Hoffmann, Peter C.G. Nijssen, Guus N. Beute, Jeroen P.P. van Vugt, Mathieu W.P.M. Lenders, M. Fiorella Contarino, Lo J. Bour

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20 Scopus citations

Abstract

Background: The aim of this study was to assess psychiatric and social outcome 12 months after bilateral deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) and subthalamic nucleus (STN) for advanced Parkinson's disease (PD). Methods: We randomly assigned patients to receive GPi DBS (n=65) or STN DBS (n=63). Standardized psychiatric and social questionnaires were assessed at baseline and after 12 months. Results: No differences were found between GPi DBS and STN DBS on psychiatric evaluation. Within-group comparisons showed small but statistically significant changes on several measures in both groups. Descriptive statistics indicated slight changes in social functioning. Marital satisfaction of patients and partners remained relatively stable after GPi and STN DBS. Conclusions: We found neither differences in psychiatric and social outcome between GPi DBS and STN DBS nor any relevant within-group differences. The decision for GPi DBS or STN DBS cannot be based on expected psychiatric or social effects.

Original language	English
Pages (from-to)	409-413
Number of pages	5
Journal	Movement Disorders
Volume	31
Issue number	3
DOIs	https://doi.org/10.1002/mds.26468
State	Published - 1 Mar 2016
Externally published	Yes

Keywords

Deep brain stimulation
Parkinson's disease
Psychiatry
Randomized controlled trial

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Boel, J. A., Odekerken, V. J. J., Geurtsen, G. J., Schmand, B. A., Cath, D. C., Figee, M., van den Munckhof, P., de Haan, R. J., Schuurman, P. R., de Bie, R. M. A., van Laar, T., van Dijk, J. M. C., Mosch, A., Hoffmann, C. F. E., Nijssen, P. C. G., Beute, G. N., van Vugt, J. P. P., Lenders, M. W. P. M., Contarino, M. F., & Bour, L. J. (2016). Psychiatric and social outcome after deep brain stimulation for advanced Parkinson's disease. Movement Disorders, 31(3), 409-413. https://doi.org/10.1002/mds.26468

@article{b09e701ac9554be994f3b7a43943809c,

title = "Psychiatric and social outcome after deep brain stimulation for advanced Parkinson's disease",

abstract = "Background: The aim of this study was to assess psychiatric and social outcome 12 months after bilateral deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) and subthalamic nucleus (STN) for advanced Parkinson's disease (PD). Methods: We randomly assigned patients to receive GPi DBS (n=65) or STN DBS (n=63). Standardized psychiatric and social questionnaires were assessed at baseline and after 12 months. Results: No differences were found between GPi DBS and STN DBS on psychiatric evaluation. Within-group comparisons showed small but statistically significant changes on several measures in both groups. Descriptive statistics indicated slight changes in social functioning. Marital satisfaction of patients and partners remained relatively stable after GPi and STN DBS. Conclusions: We found neither differences in psychiatric and social outcome between GPi DBS and STN DBS nor any relevant within-group differences. The decision for GPi DBS or STN DBS cannot be based on expected psychiatric or social effects.",

keywords = "Deep brain stimulation, Parkinson's disease, Psychiatry, Randomized controlled trial",

author = "Boel, {Judith A.} and Odekerken, {Vincent J.J.} and Geurtsen, {Gert J.} and Schmand, {Ben A.} and Cath, {Danielle C.} and Martijn Figee and {van den Munckhof}, Pepijn and {de Haan}, {Rob J.} and Schuurman, {P. Richard} and {de Bie}, {Rob M.A.} and {van Laar}, Teus and {van Dijk}, {J. Marc C.} and Arne Mosch and Hoffmann, {Carel F.E.} and Nijssen, {Peter C.G.} and Beute, {Guus N.} and {van Vugt}, {Jeroen P.P.} and Lenders, {Mathieu W.P.M.} and Contarino, {M. Fiorella} and Bour, {Lo J.}",

note = "Publisher Copyright: {\textcopyright} 2015 International Parkinson and Movement Disorder Society.",

year = "2016",

month = mar,

day = "1",

doi = "10.1002/mds.26468",

language = "English",

volume = "31",

pages = "409--413",

journal = "Movement Disorders",

issn = "0885-3185",

publisher = "John Wiley & Sons Inc.",

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Boel, JA, Odekerken, VJJ, Geurtsen, GJ, Schmand, BA, Cath, DC, Figee, M, van den Munckhof, P, de Haan, RJ, Schuurman, PR, de Bie, RMA, van Laar, T, van Dijk, JMC, Mosch, A, Hoffmann, CFE, Nijssen, PCG, Beute, GN, van Vugt, JPP, Lenders, MWPM, Contarino, MF & Bour, LJ 2016, 'Psychiatric and social outcome after deep brain stimulation for advanced Parkinson's disease', Movement Disorders, vol. 31, no. 3, pp. 409-413. https://doi.org/10.1002/mds.26468

TY - JOUR

T1 - Psychiatric and social outcome after deep brain stimulation for advanced Parkinson's disease

AU - Boel, Judith A.

AU - Odekerken, Vincent J.J.

AU - Geurtsen, Gert J.

AU - Schmand, Ben A.

AU - Cath, Danielle C.

AU - Figee, Martijn

AU - van den Munckhof, Pepijn

AU - de Haan, Rob J.

AU - Schuurman, P. Richard

AU - de Bie, Rob M.A.

AU - van Laar, Teus

AU - van Dijk, J. Marc C.

AU - Mosch, Arne

AU - Hoffmann, Carel F.E.

AU - Nijssen, Peter C.G.

AU - Beute, Guus N.

AU - van Vugt, Jeroen P.P.

AU - Lenders, Mathieu W.P.M.

AU - Contarino, M. Fiorella

AU - Bour, Lo J.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Background: The aim of this study was to assess psychiatric and social outcome 12 months after bilateral deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) and subthalamic nucleus (STN) for advanced Parkinson's disease (PD). Methods: We randomly assigned patients to receive GPi DBS (n=65) or STN DBS (n=63). Standardized psychiatric and social questionnaires were assessed at baseline and after 12 months. Results: No differences were found between GPi DBS and STN DBS on psychiatric evaluation. Within-group comparisons showed small but statistically significant changes on several measures in both groups. Descriptive statistics indicated slight changes in social functioning. Marital satisfaction of patients and partners remained relatively stable after GPi and STN DBS. Conclusions: We found neither differences in psychiatric and social outcome between GPi DBS and STN DBS nor any relevant within-group differences. The decision for GPi DBS or STN DBS cannot be based on expected psychiatric or social effects.

AB - Background: The aim of this study was to assess psychiatric and social outcome 12 months after bilateral deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) and subthalamic nucleus (STN) for advanced Parkinson's disease (PD). Methods: We randomly assigned patients to receive GPi DBS (n=65) or STN DBS (n=63). Standardized psychiatric and social questionnaires were assessed at baseline and after 12 months. Results: No differences were found between GPi DBS and STN DBS on psychiatric evaluation. Within-group comparisons showed small but statistically significant changes on several measures in both groups. Descriptive statistics indicated slight changes in social functioning. Marital satisfaction of patients and partners remained relatively stable after GPi and STN DBS. Conclusions: We found neither differences in psychiatric and social outcome between GPi DBS and STN DBS nor any relevant within-group differences. The decision for GPi DBS or STN DBS cannot be based on expected psychiatric or social effects.

KW - Deep brain stimulation

KW - Parkinson's disease

KW - Psychiatry

KW - Randomized controlled trial

UR - http://www.scopus.com/inward/record.url?scp=84952361534&partnerID=8YFLogxK

U2 - 10.1002/mds.26468

DO - 10.1002/mds.26468

M3 - Article

C2 - 26660279

AN - SCOPUS:84952361534

SN - 0885-3185

VL - 31

SP - 409

EP - 413

JO - Movement Disorders

JF - Movement Disorders

IS - 3

ER -

Psychiatric and social outcome after deep brain stimulation for advanced Parkinson's disease

Abstract

Keywords

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