Psoriasis genetics: Breaking the barrier

Elisha D.O. Roberson, Anne M. Bowcock

Research output: Contribution to journalReview articlepeer-review

180 Scopus citations

Abstract

Psoriasis is a common incurable inflammatory skin disease affecting 2-3% of the European population. Psoriatic skin contains large numbers of immune cells which produce many cytokines, chemokines and inflammatory molecules. The epidermis divides much faster than normal and has a defective outer layer or barrier which under normal circumstances protects from infection and dehydration. Psoriatic skin is characterized by a distinct set of inflammation and epidermal proliferation and differentiation markers, and it has been unclear whether the genetic basis of psoriasis reflects defects of the immune system or of the skin. One genetic determinant lies within the major histocompatibility complex class 1 region. Genome-wide association studies have revealed genetic susceptibility factors that play a role in the formation of immune cells found in psoriasis lesions. Others affect epidermal proliferation and skin barrier formation. Hence, genetic components of both the immune system and the epidermis can predispose to disease.

Original languageEnglish
Pages (from-to)415-423
Number of pages9
JournalTrends in Genetics
Volume26
Issue number9
DOIs
StatePublished - Sep 2010
Externally publishedYes

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