Pseudohypopituitary dwarfism with normal plasma growth hormone and low serum sulfation factor

Maria I. New; Ernest Schwartz; Gary A. Parks; Stephanie Landey; Eckehart Wiedemann

doi:10.1016/S0022-3476(72)80059-3

Pseudohypopituitary dwarfism with normal plasma growth hormone and low serum sulfation factor

Maria I. New, Ernest Schwartz, Gary A. Parks, Stephanie Landey, Eckehart Wiedemann

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

A 7 5/12-year-old Persian Jewish child exhibiting many typical clinical features of dwarfism associated with isolated deficiency of growth hormone was studied. Basal plasma growth hormone values were within normal limits and rose during insulin-induced hypoglycemia to high levels. The serum sulfation factor level was low and did not rise with administration of human growth hormone. Studies performed under metabolic balance conditions showed some evidence of resistance to the metabolic actions of growth hormone as well. This patient manifested clinical signs of growth hormone deficiency which were due to defective generation of sulfation factor rather than impaired growth hormone production.

Original language	English
Pages (from-to)	620-626
Number of pages	7
Journal	Journal of Pediatrics
Volume	80
Issue number	4 PART 1
DOIs	https://doi.org/10.1016/S0022-3476(72)80059-3
State	Published - Apr 1972
Externally published	Yes

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title = "Pseudohypopituitary dwarfism with normal plasma growth hormone and low serum sulfation factor",

abstract = "A 7 5/12-year-old Persian Jewish child exhibiting many typical clinical features of dwarfism associated with isolated deficiency of growth hormone was studied. Basal plasma growth hormone values were within normal limits and rose during insulin-induced hypoglycemia to high levels. The serum sulfation factor level was low and did not rise with administration of human growth hormone. Studies performed under metabolic balance conditions showed some evidence of resistance to the metabolic actions of growth hormone as well. This patient manifested clinical signs of growth hormone deficiency which were due to defective generation of sulfation factor rather than impaired growth hormone production.",

author = "New, {Maria I.} and Ernest Schwartz and Parks, {Gary A.} and Stephanie Landey and Eckehart Wiedemann",

note = "Funding Information: Supported in part by Grants HD 72, HE 12239, and AM 5350 from the National Institutes of Health, United States Public Health Service and also by Grant RR 47 from the Division of General Medical Sciences, National Institutes of Health, United States Public Health Service. Funding Information: ~'Recipient of Career Scientist Award of the Health Research Council of the City of New York under Contract 1-481.",

year = "1972",

month = apr,

doi = "10.1016/S0022-3476(72)80059-3",

language = "English",

volume = "80",

pages = "620--626",

journal = "Journal of Pediatrics",

issn = "0022-3476",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Pseudohypopituitary dwarfism with normal plasma growth hormone and low serum sulfation factor

AU - New, Maria I.

AU - Schwartz, Ernest

AU - Parks, Gary A.

AU - Landey, Stephanie

AU - Wiedemann, Eckehart

N1 - Funding Information: Supported in part by Grants HD 72, HE 12239, and AM 5350 from the National Institutes of Health, United States Public Health Service and also by Grant RR 47 from the Division of General Medical Sciences, National Institutes of Health, United States Public Health Service. Funding Information: ~'Recipient of Career Scientist Award of the Health Research Council of the City of New York under Contract 1-481.

PY - 1972/4

Y1 - 1972/4

N2 - A 7 5/12-year-old Persian Jewish child exhibiting many typical clinical features of dwarfism associated with isolated deficiency of growth hormone was studied. Basal plasma growth hormone values were within normal limits and rose during insulin-induced hypoglycemia to high levels. The serum sulfation factor level was low and did not rise with administration of human growth hormone. Studies performed under metabolic balance conditions showed some evidence of resistance to the metabolic actions of growth hormone as well. This patient manifested clinical signs of growth hormone deficiency which were due to defective generation of sulfation factor rather than impaired growth hormone production.

AB - A 7 5/12-year-old Persian Jewish child exhibiting many typical clinical features of dwarfism associated with isolated deficiency of growth hormone was studied. Basal plasma growth hormone values were within normal limits and rose during insulin-induced hypoglycemia to high levels. The serum sulfation factor level was low and did not rise with administration of human growth hormone. Studies performed under metabolic balance conditions showed some evidence of resistance to the metabolic actions of growth hormone as well. This patient manifested clinical signs of growth hormone deficiency which were due to defective generation of sulfation factor rather than impaired growth hormone production.

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JF - Journal of Pediatrics

IS - 4 PART 1

ER -

Pseudohypopituitary dwarfism with normal plasma growth hormone and low serum sulfation factor

Abstract

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