Proteomics in Malaria

Jeffrey R. Johnson; Laurence Florens; Daniel J. Carucci; John R. Yates

doi:10.1021/pr0340781

Proteomics in Malaria

Jeffrey R. Johnson
, Laurence Florens
, Daniel J. Carucci
, John R. Yates

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

The recent completion of human, Anopheles gambiae, and Plasmodium falciparum genomes relevant to the study of human malaria allows the application of modern proteomic technologies to complement previously implemented conventional approaches. Proteomic analysis has been employed to elucidate global protein expression profiles, subcellular localization of gene products, and host-pathogen interactions that are central to disease pathogenesis and treatment. The high-throughput nature of these techniques is in accord with the pace of drug and vaccine development that have the potential to directly reduce the morbidity and mortality of disease.

Original language	English
Pages (from-to)	296-306
Number of pages	11
Journal	Journal of Proteome Research
Volume	3
Issue number	2
DOIs	https://doi.org/10.1021/pr0340781
State	Published - Mar 2004
Externally published	Yes

Keywords

Malaria
Mass spectrometry
Plasmodium falciparum
Proteomics

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10.1021/pr0340781

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title = "Proteomics in Malaria",

abstract = "The recent completion of human, Anopheles gambiae, and Plasmodium falciparum genomes relevant to the study of human malaria allows the application of modern proteomic technologies to complement previously implemented conventional approaches. Proteomic analysis has been employed to elucidate global protein expression profiles, subcellular localization of gene products, and host-pathogen interactions that are central to disease pathogenesis and treatment. The high-throughput nature of these techniques is in accord with the pace of drug and vaccine development that have the potential to directly reduce the morbidity and mortality of disease.",

keywords = "Malaria, Mass spectrometry, Plasmodium falciparum, Proteomics",

author = "Johnson, \{Jeffrey R.\} and Laurence Florens and Carucci, \{Daniel J.\} and Yates, \{John R.\}",

year = "2004",

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doi = "10.1021/pr0340781",

language = "English",

volume = "3",

pages = "296--306",

journal = "Journal of Proteome Research",

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T1 - Proteomics in Malaria

AU - Johnson, Jeffrey R.

AU - Florens, Laurence

AU - Carucci, Daniel J.

AU - Yates, John R.

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Y1 - 2004/3

N2 - The recent completion of human, Anopheles gambiae, and Plasmodium falciparum genomes relevant to the study of human malaria allows the application of modern proteomic technologies to complement previously implemented conventional approaches. Proteomic analysis has been employed to elucidate global protein expression profiles, subcellular localization of gene products, and host-pathogen interactions that are central to disease pathogenesis and treatment. The high-throughput nature of these techniques is in accord with the pace of drug and vaccine development that have the potential to directly reduce the morbidity and mortality of disease.

AB - The recent completion of human, Anopheles gambiae, and Plasmodium falciparum genomes relevant to the study of human malaria allows the application of modern proteomic technologies to complement previously implemented conventional approaches. Proteomic analysis has been employed to elucidate global protein expression profiles, subcellular localization of gene products, and host-pathogen interactions that are central to disease pathogenesis and treatment. The high-throughput nature of these techniques is in accord with the pace of drug and vaccine development that have the potential to directly reduce the morbidity and mortality of disease.

KW - Malaria

KW - Mass spectrometry

KW - Plasmodium falciparum

KW - Proteomics

UR - https://www.scopus.com/pages/publications/5644269259

U2 - 10.1021/pr0340781

DO - 10.1021/pr0340781

M3 - Review article

C2 - 15113107

AN - SCOPUS:5644269259

SN - 1535-3893

VL - 3

SP - 296

EP - 306

JO - Journal of Proteome Research

JF - Journal of Proteome Research

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ER -

Proteomics in Malaria

Abstract

Keywords

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