@article{edc8a9827e6d476992985164fec3c8e5,
title = "Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity",
abstract = "Drug Toxicity Signature Generation Center (DToxS) at the Icahn School of Medicine at Mount Sinai is one of the centers for the NIH Library of Integrated Network-Based Cellular Signatures (LINCS) program. Its key aim is to generate proteomic and transcriptomic signatures that can predict cardiotoxic adverse effects of kinase inhibitors approved by the Food and Drug Administration. Towards this goal, high throughput shotgun proteomics experiments (308 cell line/drug combinations +64 control lysates) have been conducted. Using computational network analyses, these proteomic data can be integrated with transcriptomic signatures, generated in tandem, to identify cellular signatures of cardiotoxicity that may predict kinase inhibitor-induced toxicity and enable possible mitigation. Both raw and processed proteomics data have passed several quality control steps and been made publicly available on the PRIDE database. This broad protein kinase inhibitor-stimulated human cardiomyocyte proteomic data and signature set is valuable for prediction of drug toxicities.",
author = "Yuguang Xiong and Tong Liu and Tong Chen and Jens Hansen and Bin Hu and Yibang Chen and Gomathi Jayaraman and Stephan Sch{\"u}rer and Dusica Vidovic and Joseph Goldfarb and Sobie, {Eric A.} and Birtwistle, {Marc R.} and Ravi Iyengar and Hong Li and Azeloglu, {Evren U.}",
note = "Funding Information: The authors are grateful for the support from the NIH Common Fund{\textquoteright}s Library of Integrated Cellular Signatures (LINCS) grant U54 HG008098 to R.I., M.R.B., E.A.S. In addition,; H.L. is supported in part by NIH R01 GM112415; and E.U.A. is supported in part by NIH R01 DK118222. Mass spectrometer purchases were supported by NIH grant P30 NS046593 from the National Institute of Neurological Disorders and Stroke and another NIH grant 1S10 OD025047 from the Office of the Director of the National Institutes of Health. S.S. and D.V. are supported by NIH U54 HL127624. The content is sole responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
doi = "10.1038/s41597-021-01114-3",
language = "English",
volume = "9",
journal = "Scientific data",
issn = "2052-4463",
publisher = "Nature Publishing Group",
number = "1",
}