Proteomic Architecture of Valvular Extracellular Matrix: FNDC1 and MXRA5 Are New Biomarkers of Aortic Stenosis

Rihab Bouchareb; Sandra Guauque-Olarte; Justin Snider; Devyn Zaminski; Anelechi Anyanwu; Paul Stelzer; Djamel Lebeche

doi:10.1016/j.jacbts.2020.11.008

Proteomic Architecture of Valvular Extracellular Matrix: FNDC1 and MXRA5 Are New Biomarkers of Aortic Stenosis

Rihab Bouchareb
, Sandra Guauque-Olarte
, Justin Snider
, Devyn Zaminski
, Anelechi Anyanwu
, Paul Stelzer
, Djamel Lebeche

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

This study analyzed the expression of extracellular matrix (ECM) proteins during aortic valve calcification with mass spectrometry, and further validated in an independent human cohort using RNAseq data. The study reveals that valve calcification is associated with significant disruption in ECM and metabolic pathways, and highlights a strong connection between metabolic markers and ECM remodeling. It also identifies FNDC1 and MXRA5 as novel ECM biomarkers in calcified valves, electing them as potential targets in the development and progression of aortic stenosis.

Original language	English
Pages (from-to)	25-39
Number of pages	15
Journal	JACC: Basic to Translational Science
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/j.jacbts.2020.11.008
State	Published - Jan 2021

Keywords

ECM
RNA-Seq
aortic stenosis
calcified aortic valves
metabolism
proteomics

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10.1016/j.jacbts.2020.11.008

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title = "Proteomic Architecture of Valvular Extracellular Matrix: FNDC1 and MXRA5 Are New Biomarkers of Aortic Stenosis",

abstract = "This study analyzed the expression of extracellular matrix (ECM) proteins during aortic valve calcification with mass spectrometry, and further validated in an independent human cohort using RNAseq data. The study reveals that valve calcification is associated with significant disruption in ECM and metabolic pathways, and highlights a strong connection between metabolic markers and ECM remodeling. It also identifies FNDC1 and MXRA5 as novel ECM biomarkers in calcified valves, electing them as potential targets in the development and progression of aortic stenosis.",

keywords = "ECM, RNA-Seq, aortic stenosis, calcified aortic valves, metabolism, proteomics",

author = "Rihab Bouchareb and Sandra Guauque-Olarte and Justin Snider and Devyn Zaminski and Anelechi Anyanwu and Paul Stelzer and Djamel Lebeche",

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AU - Bouchareb, Rihab

AU - Guauque-Olarte, Sandra

AU - Snider, Justin

AU - Zaminski, Devyn

AU - Anyanwu, Anelechi

AU - Stelzer, Paul

AU - Lebeche, Djamel

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N2 - This study analyzed the expression of extracellular matrix (ECM) proteins during aortic valve calcification with mass spectrometry, and further validated in an independent human cohort using RNAseq data. The study reveals that valve calcification is associated with significant disruption in ECM and metabolic pathways, and highlights a strong connection between metabolic markers and ECM remodeling. It also identifies FNDC1 and MXRA5 as novel ECM biomarkers in calcified valves, electing them as potential targets in the development and progression of aortic stenosis.

AB - This study analyzed the expression of extracellular matrix (ECM) proteins during aortic valve calcification with mass spectrometry, and further validated in an independent human cohort using RNAseq data. The study reveals that valve calcification is associated with significant disruption in ECM and metabolic pathways, and highlights a strong connection between metabolic markers and ECM remodeling. It also identifies FNDC1 and MXRA5 as novel ECM biomarkers in calcified valves, electing them as potential targets in the development and progression of aortic stenosis.

KW - ECM

KW - RNA-Seq

KW - aortic stenosis

KW - calcified aortic valves

KW - metabolism

KW - proteomics

UR - https://www.scopus.com/pages/publications/85099552505

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JF - JACC: Basic to Translational Science

IS - 1

ER -

Proteomic Architecture of Valvular Extracellular Matrix: FNDC1 and MXRA5 Are New Biomarkers of Aortic Stenosis

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Keywords

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