@article{63763ae6659b4228bd7b6727828a43ce,
title = "Proteogenomic insights suggest druggable pathways in endometrial carcinoma",
abstract = "We characterized a prospective endometrial carcinoma (EC) cohort containing 138 tumors and 20 enriched normal tissues using 10 different omics platforms. Targeted quantitation of two peptides can predict antigen processing and presentation machinery activity, and may inform patient selection for immunotherapy. Association analysis between MYC activity and metformin treatment in both patients and cell lines suggests a potential role for metformin treatment in non-diabetic patients with elevated MYC activity. PIK3R1 in-frame indels are associated with elevated AKT phosphorylation and increased sensitivity to AKT inhibitors. CTNNB1 hotspot mutations are concentrated near phosphorylation sites mediating pS45-induced degradation of β-catenin, which may render Wnt-FZD antagonists ineffective. Deep learning accurately predicts EC subtypes and mutations from histopathology images, which may be useful for rapid diagnosis. Overall, this study identified molecular and imaging markers that can be further investigated to guide patient stratification for more precise treatment of EC.",
keywords = "CPTAC, CTNNB1, PIK3R1, deep learning, endometrial cancer, metformin, proteogenomics, target assays",
author = "{Clinical Proteomic Tumor Analysis Consortium} and Yongchao Dou and Lizabeth Katsnelson and Gritsenko, {Marina A.} and Yingwei Hu and Boris Reva and Runyu Hong and Wang, {Yi Ting} and Iga Kolodziejczak and Lu, {Rita Jui Hsien} and Tsai, {Chia Feng} and Wen Bu and Wenke Liu and Xiaofang Guo and Eunkyung An and Arend, {Rebecca C.} and Jasmin Bavarva and Lijun Chen and Chu, {Rosalie K.} and Andrzej Czeka{\'n}ski and Teresa Davoli and Demicco, {Elizabeth G.} and Deborah DeLair and Kelly Devereaux and Dhanasekaran, {Saravana M.} and Peter Dottino and Bailee Dover and Fillmore, {Thomas L.} and McKenzie Foxall and Hermann, {Catherine E.} and Tara Hiltke and Galen Hostetter and Marcin J{\c e}dryka and Jewell, {Scott D.} and Isabelle Johnson and Kahn, {Andrea G.} and Ku, {Amy T.} and Chandan Kumar-Sinha and Pawe{\l} Kurzawa and Lazar, {Alexander J.} and Rossana Lazcano and Lei, {Jonathan T.} and Yi Li and Yuxing Liao and Lih, {Tung Shing M.} and Lin, {Tai Tu} and Martignetti, {John A.} and Masand, {Ramya P.} and Rafa{\l} Matkowski and Pei Wang and Avi Ma'ayan",
note = "Publisher Copyright: {\textcopyright} 2023",
year = "2023",
month = sep,
day = "11",
doi = "10.1016/j.ccell.2023.07.007",
language = "English",
volume = "41",
pages = "1586--1605.e15",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "9",
}