Protein profiling of helicobacter pylori-Associated gastric cancer

Guodong Lian; Chengguo Wei; Daguang Wang; Miao Cui; Zhiqing Wang; Xiufen Liu; Wei Li; Lei Wang; Qingfeng Wang; David Y. Zhang; Jian Suo; Fei Ye

doi:10.1016/j.ajpath.2014.01.027

Protein profiling of helicobacter pylori-Associated gastric cancer

Guodong Lian, Chengguo Wei, Daguang Wang, Miao Cui, Zhiqing Wang, Xiufen Liu, Wei Li, Lei Wang, Qingfeng Wang, David Y. Zhang, Jian Suo, Fei Ye

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Helicobacter pylori infection is an initiating factor in the development of gastric cancer. Gastric cancer can be divided into two groups on the basis of H. pylori serological status; seropositive H. pylori status predicts favorable prognosis in patients with gastric cancer. By using the protein pathway array, we identified 20 differentially expressed proteins in primary gastric cancer tissues between the H. pylori-seropositive and H. pylori-seronegative groups. Our results indicate that both brassinosteroid insensitive 1-associated kinase 1 and calpastatin are favorable prognostic factors in H. pylori-seropositive gastric cancer patients. In contrast, dachshund homolog 1 is a favorable prognostic factor in H. pylori-seronegative gastric cancer patients. Different signaling pathways were found to be altered between H. pylori-seropositive and H. pylori-seronegative gastric cancer, which may account for the different tumorigenesis and outcomes between these two subsets of patients.

Original language	English
Pages (from-to)	1343-1354
Number of pages	12
Journal	American Journal of Pathology
Volume	184
Issue number	5
DOIs	https://doi.org/10.1016/j.ajpath.2014.01.027
State	Published - May 2014

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title = "Protein profiling of helicobacter pylori-Associated gastric cancer",

abstract = "Helicobacter pylori infection is an initiating factor in the development of gastric cancer. Gastric cancer can be divided into two groups on the basis of H. pylori serological status; seropositive H. pylori status predicts favorable prognosis in patients with gastric cancer. By using the protein pathway array, we identified 20 differentially expressed proteins in primary gastric cancer tissues between the H. pylori-seropositive and H. pylori-seronegative groups. Our results indicate that both brassinosteroid insensitive 1-associated kinase 1 and calpastatin are favorable prognostic factors in H. pylori-seropositive gastric cancer patients. In contrast, dachshund homolog 1 is a favorable prognostic factor in H. pylori-seronegative gastric cancer patients. Different signaling pathways were found to be altered between H. pylori-seropositive and H. pylori-seronegative gastric cancer, which may account for the different tumorigenesis and outcomes between these two subsets of patients.",

author = "Guodong Lian and Chengguo Wei and Daguang Wang and Miao Cui and Zhiqing Wang and Xiufen Liu and Wei Li and Lei Wang and Qingfeng Wang and Zhang, {David Y.} and Jian Suo and Fei Ye",

note = "Funding Information: Supported by National Natural Science Foundation of China grant 81372295 . This study was performed in partial fulfillment of the requirements for a Ph.D. degree (G.L.). ",

year = "2014",

month = may,

doi = "10.1016/j.ajpath.2014.01.027",

language = "English",

volume = "184",

pages = "1343--1354",

journal = "American Journal of Pathology",

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TY - JOUR

T1 - Protein profiling of helicobacter pylori-Associated gastric cancer

AU - Lian, Guodong

AU - Wei, Chengguo

AU - Wang, Daguang

AU - Cui, Miao

AU - Wang, Zhiqing

AU - Liu, Xiufen

AU - Li, Wei

AU - Wang, Lei

AU - Wang, Qingfeng

AU - Zhang, David Y.

AU - Suo, Jian

AU - Ye, Fei

N1 - Funding Information: Supported by National Natural Science Foundation of China grant 81372295 . This study was performed in partial fulfillment of the requirements for a Ph.D. degree (G.L.).

PY - 2014/5

Y1 - 2014/5

N2 - Helicobacter pylori infection is an initiating factor in the development of gastric cancer. Gastric cancer can be divided into two groups on the basis of H. pylori serological status; seropositive H. pylori status predicts favorable prognosis in patients with gastric cancer. By using the protein pathway array, we identified 20 differentially expressed proteins in primary gastric cancer tissues between the H. pylori-seropositive and H. pylori-seronegative groups. Our results indicate that both brassinosteroid insensitive 1-associated kinase 1 and calpastatin are favorable prognostic factors in H. pylori-seropositive gastric cancer patients. In contrast, dachshund homolog 1 is a favorable prognostic factor in H. pylori-seronegative gastric cancer patients. Different signaling pathways were found to be altered between H. pylori-seropositive and H. pylori-seronegative gastric cancer, which may account for the different tumorigenesis and outcomes between these two subsets of patients.

AB - Helicobacter pylori infection is an initiating factor in the development of gastric cancer. Gastric cancer can be divided into two groups on the basis of H. pylori serological status; seropositive H. pylori status predicts favorable prognosis in patients with gastric cancer. By using the protein pathway array, we identified 20 differentially expressed proteins in primary gastric cancer tissues between the H. pylori-seropositive and H. pylori-seronegative groups. Our results indicate that both brassinosteroid insensitive 1-associated kinase 1 and calpastatin are favorable prognostic factors in H. pylori-seropositive gastric cancer patients. In contrast, dachshund homolog 1 is a favorable prognostic factor in H. pylori-seronegative gastric cancer patients. Different signaling pathways were found to be altered between H. pylori-seropositive and H. pylori-seronegative gastric cancer, which may account for the different tumorigenesis and outcomes between these two subsets of patients.

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DO - 10.1016/j.ajpath.2014.01.027

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SN - 0002-9440

VL - 184

SP - 1343

EP - 1354

JO - American Journal of Pathology

JF - American Journal of Pathology

IS - 5

ER -

Protein profiling of helicobacter pylori-Associated gastric cancer

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