Protein Glycosylation as a Diagnostic and Prognostic Marker of Chronic Inflammatory Gastrointestinal and Liver Diseases

Xavier Verhelst, Ana M. Dias, Jean Frederic Colombel, Severine Vermeire, Hans Van Vlierberghe, Nico Callewaert, Salomé S. Pinho

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations

Abstract

Glycans are sequences of carbohydrates that are added to proteins or lipids to modulate their structure and function. Glycans modify proteins required for regulation of immune cells, and alterations have been associated with inflammatory conditions. For example, specific glycans regulate T-cell activation, structures, and functions of immunoglobulins; interactions between microbes and immune and epithelial cells; and malignant transformation in the intestine and liver. We review the effects of protein glycosylation in regulation of gastrointestinal and liver functions, and how alterations in glycosylation serve as diagnostic or prognostic factors, or as targets for therapy.

Original languageEnglish
Pages (from-to)95-110
Number of pages16
JournalGastroenterology
Volume158
Issue number1
DOIs
StatePublished - Jan 2020

Keywords

  • Glycan
  • Glycome
  • Glycomic
  • Glycosylation
  • IBD
  • Liver Disease

Fingerprint

Dive into the research topics of 'Protein Glycosylation as a Diagnostic and Prognostic Marker of Chronic Inflammatory Gastrointestinal and Liver Diseases'. Together they form a unique fingerprint.

Cite this