Abstract
The quantitative protective effects of alpha-tocopherol acid and alpha-tocopherol acid succinate on mutagen-induced genotoxicity were studied in human lymphoblastoid cell lines and lymphocytes from cultures of peripheral blood. Both agents showed a dose-dependent protection both in lymphoblastoid cell lines and in lymphocytes of head and neck cancer patients. The concentrations used were in the phatmacologic concentration range of vitamin E. The protection against genetic toxic effects may be an important part of the cancer-protective effects of vitamin E.
| Original language | English |
|---|---|
| Pages (from-to) | 325-327 |
| Number of pages | 3 |
| Journal | Anticancer Research |
| Volume | 12 |
| Issue number | 2 |
| State | Published - 1992 |
| Externally published | Yes |
Keywords
- Bleomycin
- Chemoprevention
- Clastogens
- Genotoxicity
- Vitamin E
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