Proteases stimulate mouse erythroleukemia cell differentiation and multiplication

William Scher, Barbara M. Scher, Samuel Waxman

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Seventeen different commercially available proteases stimulate both mouse erythroleukemia (MEL) cell differentiation and multiplication. These are the first enzymes shown to stimulate these processes in Friend leukemia virus-infected MEL cells. The induction of differentiation by proteases can be synergistically enhanced by the addition of low concentrations of dimethyl sylfoxide or other low molecular weight inducers. Since proteases are the first inducers of differentiation with a known biochemical function, their study should facilitate the understanding of the molecular mechanism of this process.

Original languageEnglish
Pages (from-to)348-354
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume109
Issue number2
DOIs
StatePublished - 30 Nov 1982

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