Abstract
Seventeen different commercially available proteases stimulate both mouse erythroleukemia (MEL) cell differentiation and multiplication. These are the first enzymes shown to stimulate these processes in Friend leukemia virus-infected MEL cells. The induction of differentiation by proteases can be synergistically enhanced by the addition of low concentrations of dimethyl sylfoxide or other low molecular weight inducers. Since proteases are the first inducers of differentiation with a known biochemical function, their study should facilitate the understanding of the molecular mechanism of this process.
Original language | English |
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Pages (from-to) | 348-354 |
Number of pages | 7 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 109 |
Issue number | 2 |
DOIs | |
State | Published - 30 Nov 1982 |