Prostate volume and its correlation with histopathological outcomes in prostate cancer

Prasanna Sooriakumaran, Abhishek Srivastava, Dhristie Bhagat, Majnu John, Sonal Grover, Youssef El-Douaihy, Sivaram Rajan, Robert Leung, Ashutosh Tewari

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

There is a paucity of data investigating the relationship between histopathological variables of oncologic importance and prostate volume, and we aimed to investigate this. Patients and Methods: 2,207 consecutive patients who underwent robotic-assisted radical prostatectomy were studied. Preoperative demographic and both pre- and postoperative histopathological parameters were compared among the small (<40 cm3), intermediate (40-70 cm 3), and large (>70 cm3) prostate groups. Results: Patients with smaller prostates were younger, had slightly lower BMIs, and lower prostate-specific antigen (PSA) levels than those with larger prostates (p < 0.001). They also had worse histopathological criteria (Gleason, core positivity, and maximum percent cancer) on preoperative biopsy and had worse radical specimen Gleason sums (p < 0.001), percent cancer (p < 0.001), and pathological stage (p = 0.016). 11.5% of the men in the small prostate group suffered a positive surgical margin (PSM) compared to 8.3 and 5.6% in the intermediate and large prostate groups, respectively (p = 0.008). Basilar, posterolateral, and multifocal PSMs were commoner in the small prostate group. Conclusions: Younger men have smaller prostates and worse preoperative histopathological parameters despite lower PSA values. Men with small prostates undergoing robotic-assisted radical prostatectomy have worse final Gleason sums, tumour volume, extraprostatic extension, and PSM rates than those with larger prostates.

Original languageEnglish
Pages (from-to)152-155
Number of pages4
JournalUrologia Internationalis
Volume86
Issue number2
DOIs
StatePublished - Mar 2011
Externally publishedYes

Keywords

  • Extraprostatic extension
  • Histopathology
  • Positive surgical margins
  • Prostate volume

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