TY - JOUR
T1 - Prostate cancer risk factors in black and white men in the NIH-AARP Diet and Health Study
AU - Layne, Tracy M.
AU - Graubard, Barry I.
AU - Ma, Xiaomei
AU - Mayne, Susan T.
AU - Albanes, Demetrius
N1 - Funding Information:
Funding This work was supported by the Yale-NCI pre-doctoral training grant T32 CA105666 to STM and XM, and by the Intramural Research Program of the National Cancer Institute at the National Institutes of Health.
Funding Information:
Acknowledgements This research was supported [in part] by the Intramural Research Program of the NIH, National Cancer Institute. Cancer incidence data from the Atlanta metropolitan area were collected by the Georgia Center for Cancer Statistics, Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia. Cancer incidence data from California were collected by the California Cancer Registry, California Department of Public Health’s Cancer Surveillance and Research Branch, Sacramento, California. Cancer incidence data from the Detroit metropolitan area were collected by the Michigan Cancer Surveillance Program, Community Health Administration, Lansing, Michigan. The Florida cancer incidence data used in this report were collected by the Florida Cancer Data System (Miami, Florida) under contract with the Florida Department of Health, Tallahassee, Florida. The views expressed herein are solely those of the authors and do not necessarily reflect
Publisher Copyright:
© 2018, Springer Nature Limited.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Background: There are few prospective studies comparing race-specific associations between diet, nutrients, and health-related parameters, and prostate cancer risk. Methods: Race-specific prostate cancer risk associations were examined among men in the National Institutes of Health (NIH)-AARP Diet and Health Study. We identified 1417 cases among black men (209 advanced), and 28,845 among white men (3898 advanced). Cox proportional hazards regression models estimated hazard ratios (HRs) and 95% confidence intervals (CIs). We also evaluated the cumulative change in the HR for black race following adjustment for each factor. Results: Race-specific prostate cancer associations were similar in black and white men across disease subtypes only for history of diabetes (overall : HR = 0.77, 95% CI: 0.65–0.90 and HR = 0.72, 95% CI: 0.69–0.76, respectively; P interaction = 0.66). By contrast, there was a positive risk association with height for white men and inverse for black men (P interaction : non-advanced = 0.01; advanced = 0.04). This difference remained among men with at least 2 years of follow-up for non-advanced (P interaction = 0.01), but not advanced disease (P interaction = 0.24); or after adjustment for prostate cancer screening (non-advanced P interaction = 0.53, advanced P interaction = 0.31). The only other evidence of interaction with race was observed for dietary vitamin D intake and non-advanced disease, but only after adjustment for screening (P interaction = 0.02). Cumulative adjustment for each factor increased the HR for black race by 32.9% for overall cancer and 12.4% for advanced disease. Conclusions: Our data suggest few of the dietary, nutrient, and health-related factors associated with prostate cancer risk in predominantly non-Hispanic white men were associated with risk in black men, and adjustment for these factors widen the black–white difference in risk. Larger studies of black men, particularly with prospective data, are needed to help identify risk factors relevant to this population.
AB - Background: There are few prospective studies comparing race-specific associations between diet, nutrients, and health-related parameters, and prostate cancer risk. Methods: Race-specific prostate cancer risk associations were examined among men in the National Institutes of Health (NIH)-AARP Diet and Health Study. We identified 1417 cases among black men (209 advanced), and 28,845 among white men (3898 advanced). Cox proportional hazards regression models estimated hazard ratios (HRs) and 95% confidence intervals (CIs). We also evaluated the cumulative change in the HR for black race following adjustment for each factor. Results: Race-specific prostate cancer associations were similar in black and white men across disease subtypes only for history of diabetes (overall : HR = 0.77, 95% CI: 0.65–0.90 and HR = 0.72, 95% CI: 0.69–0.76, respectively; P interaction = 0.66). By contrast, there was a positive risk association with height for white men and inverse for black men (P interaction : non-advanced = 0.01; advanced = 0.04). This difference remained among men with at least 2 years of follow-up for non-advanced (P interaction = 0.01), but not advanced disease (P interaction = 0.24); or after adjustment for prostate cancer screening (non-advanced P interaction = 0.53, advanced P interaction = 0.31). The only other evidence of interaction with race was observed for dietary vitamin D intake and non-advanced disease, but only after adjustment for screening (P interaction = 0.02). Cumulative adjustment for each factor increased the HR for black race by 32.9% for overall cancer and 12.4% for advanced disease. Conclusions: Our data suggest few of the dietary, nutrient, and health-related factors associated with prostate cancer risk in predominantly non-Hispanic white men were associated with risk in black men, and adjustment for these factors widen the black–white difference in risk. Larger studies of black men, particularly with prospective data, are needed to help identify risk factors relevant to this population.
UR - http://www.scopus.com/inward/record.url?scp=85052533756&partnerID=8YFLogxK
U2 - 10.1038/s41391-018-0070-9
DO - 10.1038/s41391-018-0070-9
M3 - Article
C2 - 30108373
AN - SCOPUS:85052533756
VL - 22
SP - 91
EP - 100
JO - Prostate Cancer and Prostatic Diseases
JF - Prostate Cancer and Prostatic Diseases
SN - 1365-7852
IS - 1
ER -