TY - JOUR
T1 - Prostate cancer in people with HIV
AU - Sigel, Keith
AU - Yu, Ryan
AU - Chiao, Elizabeth
AU - Deshmukh, Ashish
AU - Leapman, Michael S.
N1 - Publisher Copyright:
© 2024 Lippincott Williams and Wilkins. All rights reserved.
PY - 2024
Y1 - 2024
N2 - Purpose of review Prostate cancer burden has been rising among people with HIV (PWH), yet it remains understudied in the context of HIV infection. The objective of this review article is to summarize contemporary information on the burden, risk, and outcomes of prostate cancer for people living with HIV. Recent findings Despite a lower apparent incidence of prostate cancer in early studies for PWH compared to uninfected persons, this malignancy is now likely to be the most common tumor for US PWH. Tumor characteristics and stage appear to have limited differences by HIV status. The optimal approach to early detection of prostate cancer remains controversial, and there are little HIV-specific data surrounding screening. Prostate cancer outcomes may have been worse for PWH in the early antiretroviral era but may have improved in more recent years. Summary Prostate cancer is an increasingly common clinical issue for PWH. Lower than expected incidence rates in the early ART-era may be increasing, and oncologic outcomes may also be improving. Treatment tolerability is still a key question for this patient group. Given the clinical and biological complexity of chronic HIV infection, strategies for both early detection and treatment will need continued evaluation specifically in the setting of HIV. 7copy; 2024 Wolters Kluwer Health, Inc. All rights reserved.
AB - Purpose of review Prostate cancer burden has been rising among people with HIV (PWH), yet it remains understudied in the context of HIV infection. The objective of this review article is to summarize contemporary information on the burden, risk, and outcomes of prostate cancer for people living with HIV. Recent findings Despite a lower apparent incidence of prostate cancer in early studies for PWH compared to uninfected persons, this malignancy is now likely to be the most common tumor for US PWH. Tumor characteristics and stage appear to have limited differences by HIV status. The optimal approach to early detection of prostate cancer remains controversial, and there are little HIV-specific data surrounding screening. Prostate cancer outcomes may have been worse for PWH in the early antiretroviral era but may have improved in more recent years. Summary Prostate cancer is an increasingly common clinical issue for PWH. Lower than expected incidence rates in the early ART-era may be increasing, and oncologic outcomes may also be improving. Treatment tolerability is still a key question for this patient group. Given the clinical and biological complexity of chronic HIV infection, strategies for both early detection and treatment will need continued evaluation specifically in the setting of HIV. 7copy; 2024 Wolters Kluwer Health, Inc. All rights reserved.
KW - HIV
KW - non-AIDS defining cancer
KW - prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=85211094216&partnerID=8YFLogxK
U2 - 10.1097/QCO.0000000000001076
DO - 10.1097/QCO.0000000000001076
M3 - Review article
AN - SCOPUS:85211094216
SN - 0951-7375
JO - Current Opinion in Infectious Diseases
JF - Current Opinion in Infectious Diseases
M1 - 10.1097/QCO.0000000000001076
ER -